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Elevated N-acetyl-beta-D-glucosaminidase, a urinary tubular damage marker, is a significant predictor of carotid artery atherosclerosis in type 1 diabetes, independent of albuminuria: A cross-sectional study

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author이민영-
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.contributor.author차봉수-
dc.contributor.author홍남기-
dc.date.accessioned2018-09-28T08:56:26Z-
dc.date.available2018-09-28T08:56:26Z-
dc.date.issued2018-
dc.identifier.issn1056-8727-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163244-
dc.description.abstractAIMS: Recent evidence has shown that renal tubulointerstitial injuries play an important role in diabetic nephropathy. In this study, we evaluated the association between urinary N-acetyl-β-d-glucosaminidase (uNAG), an early renal tubular damage marker, and carotid artery atherosclerosis in patients with type 1 diabetes (T1D). METHODS: This was a cross-sectional study of 88 patients with T1D. Demographic and laboratory data; urinary indices, including urinary NAG-to-creatinine ratio (uNCR), and albumin-to-creatinine ratio (uACR); and carotid ultrasonography were investigated. RESULTS: Eighty-eight subjects were divided into three groups based on uNCR tertiles. Subjects belonging to the highest tertile of uNCR had the highest average mean and maximum carotid intima-media thickness (IMT). An elevated uNCR was also significantly correlated with increased average mean and maximum carotid IMT, whereas an elevated uACR was not. Even after adjusting for confounding factors, uNCR continued to be a meaningful predictive marker for increased average mean and maximum IMT. Conversely, the uACR could not predict carotid IMT after adjustment for confounding factors. CONCLUSIONS: Elevated levels of uNAG are significantly associated with carotid artery atherosclerosis in patients with T1D independently of albuminuria, a marker of glomerular damage.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Pub. Co.-
dc.relation.isPartOfJOURNAL OF DIABETES AND ITS COMPLICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleElevated N-acetyl-beta-D-glucosaminidase, a urinary tubular damage marker, is a significant predictor of carotid artery atherosclerosis in type 1 diabetes, independent of albuminuria: A cross-sectional study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorMinyoung Lee-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorByung-Wan Lee-
dc.identifier.doi10.1016/j.jdiacomp.2018.05.019-
dc.contributor.localIdA00068-
dc.contributor.localIdA05491-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA04388-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ01376-
dc.identifier.eissn1873-460X-
dc.identifier.pmid29980431-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1056872717317105-
dc.subject.keywordAlbuminuria-
dc.subject.keywordCarotid intima-media thickness-
dc.subject.keywordN-acetyl-β-d-glucosaminidase-
dc.subject.keywordRenal tubules-
dc.subject.keywordType 1 diabetes mellitus-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameLee, Minyoung-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameHong, Nam Ki-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorLee, Minyoung-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorHong, Namki-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.citation.volume32-
dc.citation.number8-
dc.citation.startPage777-
dc.citation.endPage783-
dc.identifier.bibliographicCitationJOURNAL OF DIABETES AND ITS COMPLICATIONS, Vol.32(8) : 777-783, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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