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Radon Exposure-induced Genetic Variations in Lung Cancers among Never Smokers

DC Field Value Language
dc.contributor.author김혜련-
dc.date.accessioned2018-09-28T08:52:42Z-
dc.date.available2018-09-28T08:52:42Z-
dc.date.issued2018-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163185-
dc.description.abstractBackground: Lung cancer in never smokers (LCINS) differs etiologically and clinically from lung cancer attributed to smoking. After smoking, radon exposure is the second leading cause and the primary risk factor of lung cancer among never smokers. Exposure to radon can lead to genetic and epigenetic alterations in tumor genomes affecting genes and pathways involved in lung cancer development. The present study sought to explore genetic alterations associated with LCINS exposed to radon gas indoors. Methods: Genetic associations were assessed via a case-control study of LCINS (39 cases and 30 controls) using next generation sequencing. Associations between genetic mutations and high exposure to radon were investigated by OncoPrint and heatmap graphs. Bioinformatic analysis was conducted using various tools. According radon exposure levels, we divided subjects in two groups of cases and controls. Results: We found that ABL2 rs117218074, SMARCA4 rs2288845, PIK3R2 rs142933317, MAPK1 rs1803545, and androgen receptor (AR) rs66766400 were associated with LCINS exposed to high radon levels. Among these, Chromodomain helicase DNA-binding protein 4 (CHD4) rs74790047, TSC2 rs2121870, and AR rs66766408 were identified as common exonic mutations in both lung cancer patients and normal individuals exposed to high levels of radon indoor. Conclusion: We identified that CHD4 rs74790047, TSC2 rs2121870, and AR rs66766408 are found to be common exonic mutations in both lung cancer patients and normal individuals exposed to radon indoors. Further analysis is needed to determine whether these genes are completely responsible for LCINS exposed to residential radon.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRadon Exposure-induced Genetic Variations in Lung Cancers among Never Smokers-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJung Ran Choi-
dc.contributor.googleauthorSang Baek Koh-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorHyojin Lee-
dc.contributor.googleauthorDae Ryong Kang-
dc.identifier.doi10.3346/jkms.2018.33.e207-
dc.contributor.localIdA01166-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid30008631-
dc.subject.keywordGenetic Alteration-
dc.subject.keywordLung Cancer in Never Smokers-
dc.subject.keywordNext Generation Sequencing-
dc.subject.keywordRadon Exposure-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.citation.volume33-
dc.citation.number29-
dc.citation.startPagee207-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.33(29) : e207, 2018-
dc.identifier.rimsid58453-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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