Cited 11 times in
Clinical Parameters to Distinguish Silent Corticotroph Adenomas from Other Nonfunctioning Pituitary Adenomas.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구철룡 | - |
dc.contributor.author | 김다함 | - |
dc.contributor.author | 김선호 | - |
dc.contributor.author | 김의현 | - |
dc.contributor.author | 문주형 | - |
dc.contributor.author | 박세희 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2018-09-28T08:52:09Z | - |
dc.date.available | 2018-09-28T08:52:09Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1878-8750 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163175 | - |
dc.description.abstract | BACKGROUND: It is difficult to distinguish silent corticotroph adenomas (SCAs) from other nonfunctioning pituitary adenomas (NFPAs) preoperatively. This study aimed to determine the preoperative clinical parameters associated with SCAs. METHODS: This was a retrospective single-center study of patients who underwent surgery for NFPAs during 2011-2016 in our tertiary hospital and who had preoperative combined pituitary function test (CPFT) and immunohistochemical staining results available. After we excluded patients with increased 24-hour urinary free cortisol to preclude overt Cushing's disease, 341 patients were finally enrolled. The medical records, including the CPFT and immunohistochemistry results, of the patients were reviewed. RESULTS: The age and tumor size were similar between patients with SCAs and other NFPAs. The SCA group had a greater proportion of women (89.2% vs. 57.6%, P < 0.001), cavernous sinus invasion (35.1% vs. 20.7%, P = 0.047), and intratumoral hemorrhage on preoperative sella magnetic resonance imaging (32.4% vs. 9.2%, P < 0.001) compared with the NFPA group. In the preoperative CPFT, the cortisol response was not significantly different between groups. However, the peak adrenocorticotropic hormone (ACTH) (67.80 ± 49.83 vs. 85.67 ± 78.97 pg/mL, P = 0.061) tended to be lower, and the ΔACTH (53.71 ± 50.14 vs. 72.67 ± 75.82 pg/mL, P = 0.046) was significantly lower in SCAs. After we excluded patients with preoperative hypopituitarism caused by mass effects, the peak ACTH (69.39 ± 39.45 vs. 119.75 ± 89.84 pg/mL, P = 0.001) and ΔACTH (58.58 ± 36.51 vs. 107.66 ± 86.05 pg/mL, P = 0.001) were significantly lower in SCAs than in other NFPAs. CONCLUSIONS: Female sex, cavernous sinus invasion, intratumoral hemorrhage on sella magnetic resonance imaging, and decreased ACTH response in the CPFT are independent indicators of SCAs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | WORLD NEUROSURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ACTH-Secreting Pituitary Adenoma/diagnosis | - |
dc.subject.MESH | ACTH-Secreting Pituitary Adenoma/surgery* | - |
dc.subject.MESH | Adrenocorticotropic Hormone/pharmacology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cavernous Sinus/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypopituitarism/surgery* | - |
dc.subject.MESH | Immunohistochemistry/methods | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pituitary ACTH Hypersecretion/surgery* | - |
dc.subject.MESH | Pituitary Neoplasms/diagnosis | - |
dc.subject.MESH | Pituitary Neoplasms/surgery* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Clinical Parameters to Distinguish Silent Corticotroph Adenomas from Other Nonfunctioning Pituitary Adenomas. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Daham Kim | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Se Hee Park | - |
dc.contributor.googleauthor | Ju Hyung Moon | - |
dc.contributor.googleauthor | Eui Hyun Kim | - |
dc.contributor.googleauthor | Sun Ho Kim | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.1016/j.wneu.2018.04.070 | - |
dc.contributor.localId | A00201 | - |
dc.contributor.localId | A00363 | - |
dc.contributor.localId | A00560 | - |
dc.contributor.localId | A00837 | - |
dc.contributor.localId | A01383 | - |
dc.contributor.localId | A01525 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J02806 | - |
dc.identifier.eissn | 1878-8769 | - |
dc.identifier.pmid | 29678704 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1878875018307885 | - |
dc.subject.keyword | ACTH | - |
dc.subject.keyword | Corticotroph cells | - |
dc.subject.keyword | Cushing's disease | - |
dc.subject.keyword | Nonfunctioning adenoma | - |
dc.subject.keyword | Pituitary adenoma | - |
dc.contributor.alternativeName | Ku, Cheol Ryong | - |
dc.contributor.alternativeName | Kim, Da Ham | - |
dc.contributor.alternativeName | Kim, Sun Ho | - |
dc.contributor.alternativeName | Kim, Eui Hyun | - |
dc.contributor.alternativeName | Moon, Ju Hyung | - |
dc.contributor.alternativeName | Park, Se Hee | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Ku, Cheol Ryong | - |
dc.contributor.affiliatedAuthor | Kim, Da Ham | - |
dc.contributor.affiliatedAuthor | Kim, Sun Ho | - |
dc.contributor.affiliatedAuthor | Kim, Eui Hyun | - |
dc.contributor.affiliatedAuthor | Moon, Ju Hyung | - |
dc.contributor.affiliatedAuthor | Park, Se Hee | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.citation.volume | 115 | - |
dc.citation.startPage | e464 | - |
dc.citation.endPage | e471 | - |
dc.identifier.bibliographicCitation | WORLD NEUROSURGERY, Vol.115 : e464-e471, 2018 | - |
dc.identifier.rimsid | 58443 | - |
dc.type.rims | ART | - |
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