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Effect of Bio Function Enhanced-Dual TiO2 Nanotube Implants on Osseointegration: A Comparative Study in Rabbit Model

Authors
 Lee, Jae-Heon  ;  Choi, Hyunmin  ;  Lee, Jae-Hoon  ;  Cho, Sung-Won  ;  Oh, Seunghan  ;  Shim, June-Sung  ;  Park, Young-Bum 
Citation
 JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, Vol.8(6) : 783-791, 2018 
Journal Title
 JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 
ISSN
 2157-9083 
Issue Date
2018
Keywords
DENTAL IMPLANT ; DUAL TIO2 NANOTUBE ; NANOTECHNOLOGY ; OSSEOINTEGRATION ; SURFACE MODIFICATION
Abstract
The purpose of this study is to evaluate the effect of dual TiO2 nanotube implant on osseointegration in rabbit. A dual TiO2 nanotube implant, consisting of various combinations of two different nanotube sizes, was divided into four groups: 8 nm/30 nm, 8 nm/70 nm, 30 nm/70 nm, and 30 nm/100 nm TiO2 nanotube. A total of 40 dual TiO2 nanotube implants were fabricated and implanted to the tibia of rabbits, which were then sacrificed after 2 and 12 weeks. The level of osseointegration was compared among the groups throughout the radiologic, histological, and histomorphometric analysis. The micro-CT analysis results showed that the bone volume (BV) value (%) of 12-week group was higher than that of 2-week group overall, and 8/30 group within the 2-week group and 30/100 group within the 12-week group displayed the highest BV value (p > 0.05). The histologic and histomorphometric analysis also showed that the recession (%) around the micro-thread was significantly lower in the 12-week group than in the 2-week group (p < 0.05), and 8/70 group within the 2-week group and 30/70 group and 30/100 group within the 12-week group presented the lowest value. The area of the new bone (μm2) formed above upper cortical bone border was the largest in 30/70 group within the 2-week group and in 30/100 group within the 12-week group (p > 0.05). The bone to implant contact (BIC) value (%) measured within the bone marrow exhibited that 8/30 group in the 2-week group and 8/70 group in the 12-week group had the highest (p > 0.05), while the BV value (%) measured within the marrow revealed that 30/100 groups in both of 2-week and 12-week groups had the highest (p > 0.05).
Full Text
https://www.ingentaconnect.com/contentone/asp/jbte/2018/00000008/00000006/art00004
DOI
10.1166/jbt.2018.1809
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Bum(박영범)
Shim, June Sung(심준성) ORCID logo https://orcid.org/0000-0003-1428-0122
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0003-2281-8885
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163168
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