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Recombinant batroxobin-coated nonwoven chitosan as hemostatic dressing for initial hemorrhage control

Authors
 Gyeung Mi Seon  ;  Mi Hee Lee  ;  Byeong-Ju Kwon  ;  Min Sung Kim  ;  Min-Ah Koo  ;  Young Seomun  ;  Jong-Tak Kim  ;  Tae Hee Kim  ;  Jong-Chul Park 
Citation
 International Journal of Biological Macromolecules, Vol.113 : 757-763, 2018 
Journal Title
 International Journal of Biological Macromolecules 
ISSN
 0141-8130 
Issue Date
2018
Keywords
Hemostasis ; Nonwoven chitosan ; Recombinant batroxobin
Abstract
The choice of hemostat is determined by the situation and the degree of hemorrhage. One common hemostat, the nonwoven dressing, is easy to handled and controls severe bleeding on wider wounds. In this study, chitosan-based nonwoven dressings with recombinant batroxobin (rBat) were used as efficacious hemostatic dressing agents. Hemostatic agents need to absorb blood quickly in the early stages of blood coagulation cascade to rapidly and effectively control of excessive hemorrhages. To date, most studies of hemostatic agents focused on a single material and hemostats composed of multiple materials have not been studied sufficiently. Thus, we made a chitosan dressing coated with rBat and investigated the microstructure, mechanical properties, hemostatic efficacy, and clotting properties of the coated dressing. Our results showed that the rBat had a synergetic effect on chitosan that improved blood coagulation. Furthermore, the dressing had excellent bleeding control in an Sprague-Dawley (SD) rat femoral artery hemorrhage model. In conclusion, hemostasis can be improved by combining a chitosan-based nonwoven dressing with other agents, and rBat-coated chitosan-based nonwoven dressings have enormous potential to improve blood coagulation.
Full Text
https://www.sciencedirect.com/science/article/pii/S0141813017344306
DOI
10.1016/j.ijbiomac.2018.03.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
구민아(Koo, Min-Ah) ORCID logo https://orcid.org/0000-0002-8671-1131
권병주(Kwon, Byeong-Ju) ORCID logo https://orcid.org/0000-0001-9916-0546
박종철(Park, Jong Chul) ORCID logo https://orcid.org/0000-0003-0083-5991
선경미(Seon, Gyeung Mi) ORCID logo https://orcid.org/0000-0002-0766-1106
이미희(Lee, Mi Hee) ORCID logo https://orcid.org/0000-0002-9630-7044
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163161
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