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The possibility of hormone-mediated PSA derangement in prostate cancer treatment
DC Field | Value | Language |
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dc.contributor.author | 이창걸 | - |
dc.date.accessioned | 2018-09-28T08:51:25Z | - |
dc.date.available | 2018-09-28T08:51:25Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2322-3243 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163160 | - |
dc.description.abstract | Background: This study was designed to suggest the possibility of hormone-related derangement in salvage radiotherapy (SRT) after radical prostatectomy in terms of prostate-specific antigen (PSA) control. Materials and Methods: Among 160 consecutive prostate cancer patients who received radical prostatectomy, 34 with SRT between 2004 and 2012 were retrospectively reviewed. The numbers of patients with pathologic T3-T4 stage, Gleason score 8-10, and positive resection margin were 11 (32.4%), 10 (29.4%), and 17 (50.0%), respectively. Median SRT dose was 64.8 Gy (range, 52.9-70.0 Gy) with 1.8-2.3 Gy fractionations. Biochemical failure-free survival after SRT was counted and the median follow-up period was 32.5 months (range, 10-118 months). Results: After SRT, the median time for PSA to decrease to less than 0.2 ng/mL was four months (range, 0-25 months). The three-year survival rate was 60.3%. On univariate analysis, preferential hormone therapy (PHT) (p=0.022), higher PSA at SRT (p=0.005), and higher PSA after surgery (p=0.003) were related to a shorter biochemical survival period. On multivariate analysis, lower PSA at SRT (p=0.016), higher radiation dose (p=0.007), and non-PHT (p=0.046) suggested a consistent PSA control. Conclusion: According to these results, low PSA values by hormonal intervention need to be reconsidered with a different way to look at the relationship between the PSA and hormone therapy. SRT should be considered for postoperative salvage treatment regardless of the hormone-related PSA values. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Baresh-e-Danesh Press | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The possibility of hormone-mediated PSA derangement in prostate cancer treatment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | C.G. Lee | - |
dc.contributor.googleauthor | J. Lee | - |
dc.contributor.googleauthor | S. Kim | - |
dc.contributor.googleauthor | S.H. You | - |
dc.identifier.doi | 10.18869/acadpub.ijrr.16.2.243 | - |
dc.contributor.localId | A03240 | - |
dc.relation.journalcode | J03457 | - |
dc.identifier.eissn | 2345-4229 | - |
dc.identifier.url | http://ijrr.com/browse.php?a_id=2242&sid=1&slc_lang=en | - |
dc.subject.keyword | Hormone therapy | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | Salvage radiotherapy | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 243 | - |
dc.citation.endPage | 250 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION RESEARCH, Vol.16(2) : 243-250, 2018 | - |
dc.identifier.rimsid | 58429 | - |
dc.type.rims | ART | - |
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