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Non-cardioembolic risk factors in atrial fibrillation-associated ischemic stroke.

DC Field Value Language
dc.contributor.author김영대-
dc.contributor.author김태훈-
dc.contributor.author남효석-
dc.contributor.author박동혁-
dc.contributor.author박희남-
dc.contributor.author양필성-
dc.contributor.author엄재선-
dc.contributor.author유준상-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.contributor.author허지회-
dc.date.accessioned2018-09-28T08:51:02Z-
dc.date.available2018-09-28T08:51:02Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163154-
dc.description.abstractINTRODUCTION: Cardioembolic (CE) risks is usually considered as the main mechanism of ischemic stroke in non-valvular atrial fibrillation (NVAF) patients. However, a substantial number of ischemic strokes in NVAF patients are related to non-CE mechanisms. The aim of this study was to investigate the non-CE risk factors in ischemic stroke patients had NVAF. METHODS: We included 401 patients (65.6% male, 68.6 ± 9.6 years old) who had been hospitalized due to ischemic stroke and had a known or newly diagnosed NVAF. The CE (intracardiac thrombus, dense spontaneous echo contrast, or low left atrial appendage flow velocity) and non-CE (complex aortic plaque, significant carotid stenosis, or intracranial arterial stenosis) risk factors were investigated at the time of the index stroke. RESULTS: The number of CE and non-CE risk factors increased with increasing CHA2DS2-VASc scores (p for trends < 0.001). The presence of CE risk factors was independently associated with persistent atrial fibrillation (p < 0.001), body mass index (p = 0.003), heart failure (p = 0.003), and left atrial volume index (p < 0.001). In contrast, the presence of non-CE risk factors was independently associated with age (p < 0.001), hypertension (p = 0.049), diabetes (p = 0.030), and coronary artery calcium score (CACS; p < 0.001). CACS had the added value in predicting non-CE risk factors of ischemic stroke regardless of the CHA2DS2-VASc risk category (p < 0.001). CONCLUSION: Non-CE risk factors in ischemic stroke patients with NVAF are associated with high CHA2DS2-VASc score and CACS. Atherosclerotic non-CE risk factors should be considered as potential mechanisms of stroke even in patients with AF-associated ischemic stroke.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleNon-cardioembolic risk factors in atrial fibrillation-associated ischemic stroke.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorPil-Sung Yang-
dc.contributor.googleauthorHui-Nam Pak-
dc.contributor.googleauthorDong-Hyuk Park-
dc.contributor.googleauthorJoonsang Yoo-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorJi Hoe Heo-
dc.identifier.doi10.1371/journal.pone.0201062-
dc.contributor.localIdA00702-
dc.contributor.localIdA05466-
dc.contributor.localIdA01273-
dc.contributor.localIdA01455-
dc.contributor.localIdA01776-
dc.contributor.localIdA02323-
dc.contributor.localIdA02337-
dc.contributor.localIdA02513-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid30028885-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.alternativeNameKim, Tae-Hoon-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNamePark, Dong Hyuk-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameYang, Pil Sung-
dc.contributor.alternativeNameUhm, Jae Sun-
dc.contributor.alternativeNameYoo, Joon Sang-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.affiliatedAuthorKim, Young Dae-
dc.contributor.affiliatedAuthorKim, Tae Hoon-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorPark, Dong Hyuk-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorYang, Pil Sung-
dc.contributor.affiliatedAuthorUhm, Jae Sun-
dc.contributor.affiliatedAuthorYoo, Joon Sang-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.citation.volume13-
dc.citation.number7-
dc.citation.startPagee0201062-
dc.identifier.bibliographicCitationPLOS ONE, Vol.13(7) : e0201062, 2018-
dc.identifier.rimsid58423-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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