Cited 15 times in
Inter-alpha Inhibitor H4 as a Potential Biomarker Predicting the Treatment Outcomes in Patients with Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | 성진실 | - |
dc.contributor.author | 이은정 | - |
dc.contributor.author | 전경희 | - |
dc.date.accessioned | 2018-09-28T08:50:58Z | - |
dc.date.available | 2018-09-28T08:50:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163152 | - |
dc.description.abstract | Purpose: Early prediction of treatment outcomes represents an essential step towards increased treatment efficacy and survival in patients with hepatocellular carcinoma (HCC). In this study, we performed two-dimensional electrophoresis (2-DE) followed by protein profiling to identify biomarkers predictive of therapeutic outcomes in patients with HCC who received liver-directed therapy (LDTx) involving local radiotherapy (RT), and studied the underlying mechanisms of the identified proteins. Materials and Methods: 2-DE analysis was conducted by pooling sera from patients with a good or poor prognosis; serum proteomic profiles of the two groups were compared and analyzed using matrixassisted laser desorption/ionization time-of-flight mass spectrometry. Identified proteins were confirmed via enzyme-linked immunosorbent assay. An invasion assay was performed after overexpression and knockdown of target protein in Huh7 cells. Results: Levels of inter-alpha inhibitor H4 (ITIH4), fibrinogen gamma chain, keratin 9/1 complex, carbonic anhydrase I, and carbonmonoxyhemoglobin S were changed by more than 4-fold in response to LDTx. In particular, pre-LDTx ITIH4 expression was more than 5-fold higher in patients with a good prognosis, compared to patients with a poor prognosis. The migration ability of Huh7 cells was significantly suppressed and enhanced by ITIH4 overexpression and knockdown, respectively. The tumors of patients with HCC and a good prognosis expressed high levels of ITIH4, compared to those of patients with a poor prognosis. Conclusion: Taken together, ITIH4 may be a potential therapeutic target that could inhibit cancer metastasis, as well as a prognostic marker for patients with HCC who are receiving LDTx. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Inter-alpha Inhibitor H4 as a Potential Biomarker Predicting the Treatment Outcomes in Patients with Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Eun-Jung Lee | - |
dc.contributor.googleauthor | Seung-Hyun Yang | - |
dc.contributor.googleauthor | Kyoung-Jin Kim | - |
dc.contributor.googleauthor | Hyejung Cha | - |
dc.contributor.googleauthor | Seo Jin Lee | - |
dc.contributor.googleauthor | Ji-Hye Kim | - |
dc.contributor.googleauthor | Junkyu Song | - |
dc.contributor.googleauthor | Kyung-Hee Chun | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.identifier.doi | 10.4143/crt.2016.550 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A03047 | - |
dc.contributor.localId | A03501 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 28724284 | - |
dc.subject.keyword | Biomarkers | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | ITIH4 | - |
dc.subject.keyword | Liver-directed therapy | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Lee, Eun Jung | - |
dc.contributor.alternativeName | Chun, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jung | - |
dc.contributor.affiliatedAuthor | Chun, Kyung Hee | - |
dc.citation.volume | 50 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 646 | - |
dc.citation.endPage | 657 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.50(3) : 646-657, 2018 | - |
dc.identifier.rimsid | 58421 | - |
dc.type.rims | ART | - |
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