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Clinical significance of platelet-to-lymphocyte ratio in women with preeclampsia.

 Min‐A Kim  ;  Gwan Hee Han  ;  Ja‐Young Kwon  ;  Young‐Han Kim 
 American Journal of Reproductive Immunology, Vol.80(1) : e12973, 2018 
Journal Title
 American Journal of Reproductive Immunology 
Issue Date
platelet indices ; platelet-to-lymphocyte ratio ; preeclampsia
PROBLEM: Preeclampsia (PE) is a serious pregnancy complication leading to high maternal, perinatal morbidity, and mortality. We aimed to investigate the clinical effectiveness of the platelet-to-lymphocyte ratio (PLR) in women with PE and compare this measurement to platelet indices as a diagnostic and prognostic marker of PE. METHOD OF STUDY: A total of 471 healthy pregnant women, 126 women diagnosed with mild PE, and 227 with severe PE were included in this retrospective study. We analyzed PLR and platelet indices, mainly mean platelet volume (MPV) and platelet distribution width (PDW) among the 3 groups. RESULTS: Platelet distribution width, MPV, and PLR levels in women with PE were significantly different from those of healthy pregnant women. PLR was significantly lower in severe PE than mild PE (P = .001), but PDW and MPV increased as severity of PE progressed; however, the differences in PDW and MPV between women with mild and severe PE were not significant. Receiver operating characteristic curve analysis showed that PLR was more predictive of PE than PDW and MPV (Area under the curve = 0.759 vs 0.621, 0.638). Additionally, the time interval from admission to delivery was significantly shorter in women with PLR-positive (≤116) than in women with PDW-positive (>58) and MPV-positive (>9). CONCLUSION: The PLR is an easily accessible and cost-effective parameter, which may be used as a more useful marker for prediction of PE compared to platelet indices. Our study showed that PLR can serve as a useful diagnostic marker of PE.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
권자영(Kwon, Ja Young) ORCID logo https://orcid.org/0000-0003-3009-6325
김민아(Kim, Min A)
김영한(Kim, Young Han) ORCID logo https://orcid.org/0000-0003-0645-6028
한관희(Han, Gwan Hee) ORCID logo https://orcid.org/0000-0001-5263-4855
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