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HBsAg-negative and anti-HBc-positive in eosinophilic granulomatosis with polyangiitis: a retrospective pilot study

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dc.contributor.author김도영-
dc.contributor.author박용범-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이상원-
dc.contributor.author한광협-
dc.date.accessioned2018-09-28T08:50:09Z-
dc.date.available2018-09-28T08:50:09Z-
dc.date.issued2018-
dc.identifier.issn0172-8172-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163132-
dc.description.abstractWe examined whether resolved hepatitis B virus (HBV) infection was associated with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and affected AAV activity at diagnosis and prognosis during the follow-up. We reviewed the electronic medical records of 153 AAV patients, and included 91 hepatitis B surface antigen (HBsAg)-negative patients having results of both antibody to hepatitis B core antigen (anti-HBc) and surface antigen (anti-HBs). We collected clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis and relapse rates during the follow-up. We divided patients into the two groups according to the presence of anti-HBc and compared variables between them in patients with AAV or those with each variant. The mean age and follow-up duration were 59.8 ± 15.2-year-old and 48.0 ± 47.5 months. Fifty patients (54.9%) had anti-HBc, and 61 patients (67.0%) had anti-HBs. Only thirty-six (39.6%) patients had ever experienced relapse after remission. There were no remarkable differences between HBsAg-negative AAV patients with and without anti-HBc. However, in eosinophilic granulomatosis with polyangiitis (EGPA) patients, patients with HBs-negative/anti-HBc-positive (resolved HBV infection) showed the higher initial mean BVAS and FFS (2009) than those without. Patients having anti-HBc exhibited significantly increased risk of relapse of EGPA than those having not (RR 16.0). Also, EGPA patients with HBs-negative/anti-HBc-positive showed meaningfully lower cumulative relapse-free survival rates than those without during the follow-up duration (p = 0.043). In conclusion, resolved HBV infection may importantly influence vasculitis activity at diagnosis and subsequently relapse after remission in EGPA patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfRHEUMATOLOGY INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHBsAg-negative and anti-HBc-positive in eosinophilic granulomatosis with polyangiitis: a retrospective pilot study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSang-Won Lee-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorJun Yong Park-
dc.identifier.doi10.1007/s00296-018-4043-z-
dc.contributor.localIdA00385-
dc.contributor.localIdA01579-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02824-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ02625-
dc.identifier.eissn1437-160X-
dc.identifier.pmid29754328-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00296-018-4043-z-
dc.subject.keywordANCA-associated vasculitis-
dc.subject.keywordActivity-
dc.subject.keywordEosinophilic granulomatosis with polyangiitis-
dc.subject.keywordRelapse-
dc.subject.keywordResolved HBV infection-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.citation.volume38-
dc.citation.number8-
dc.citation.startPage1531-
dc.citation.endPage1538-
dc.identifier.bibliographicCitationRHEUMATOLOGY INTERNATIONAL, Vol.38(8) : 1531-1538, 2018-
dc.identifier.rimsid58403-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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