Cited 5 times in
HBsAg-negative and anti-HBc-positive in eosinophilic granulomatosis with polyangiitis: a retrospective pilot study
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.contributor.author | 박용범 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2018-09-28T08:50:09Z | - |
dc.date.available | 2018-09-28T08:50:09Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163132 | - |
dc.description.abstract | We examined whether resolved hepatitis B virus (HBV) infection was associated with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and affected AAV activity at diagnosis and prognosis during the follow-up. We reviewed the electronic medical records of 153 AAV patients, and included 91 hepatitis B surface antigen (HBsAg)-negative patients having results of both antibody to hepatitis B core antigen (anti-HBc) and surface antigen (anti-HBs). We collected clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis and relapse rates during the follow-up. We divided patients into the two groups according to the presence of anti-HBc and compared variables between them in patients with AAV or those with each variant. The mean age and follow-up duration were 59.8 ± 15.2-year-old and 48.0 ± 47.5 months. Fifty patients (54.9%) had anti-HBc, and 61 patients (67.0%) had anti-HBs. Only thirty-six (39.6%) patients had ever experienced relapse after remission. There were no remarkable differences between HBsAg-negative AAV patients with and without anti-HBc. However, in eosinophilic granulomatosis with polyangiitis (EGPA) patients, patients with HBs-negative/anti-HBc-positive (resolved HBV infection) showed the higher initial mean BVAS and FFS (2009) than those without. Patients having anti-HBc exhibited significantly increased risk of relapse of EGPA than those having not (RR 16.0). Also, EGPA patients with HBs-negative/anti-HBc-positive showed meaningfully lower cumulative relapse-free survival rates than those without during the follow-up duration (p = 0.043). In conclusion, resolved HBV infection may importantly influence vasculitis activity at diagnosis and subsequently relapse after remission in EGPA patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | HBsAg-negative and anti-HBc-positive in eosinophilic granulomatosis with polyangiitis: a retrospective pilot study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.identifier.doi | 10.1007/s00296-018-4043-z | - |
dc.contributor.localId | A00385 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J02625 | - |
dc.identifier.eissn | 1437-160X | - |
dc.identifier.pmid | 29754328 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00296-018-4043-z | - |
dc.subject.keyword | ANCA-associated vasculitis | - |
dc.subject.keyword | Activity | - |
dc.subject.keyword | Eosinophilic granulomatosis with polyangiitis | - |
dc.subject.keyword | Relapse | - |
dc.subject.keyword | Resolved HBV infection | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.citation.volume | 38 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1531 | - |
dc.citation.endPage | 1538 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, Vol.38(8) : 1531-1538, 2018 | - |
dc.identifier.rimsid | 58403 | - |
dc.type.rims | ART | - |
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