93 161

Cited 1 times in

Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer

DC FieldValueLanguage
dc.contributor.author배숭준-
dc.contributor.author안성귀-
dc.contributor.author윤창익-
dc.contributor.author이학우-
dc.contributor.author정준-
dc.contributor.author차윤진-
dc.date.accessioned2018-08-28T17:30:11Z-
dc.date.available2018-08-28T17:30:11Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162680-
dc.description.abstractBACKGROUND: Recent studies have shown that tumors with extensive tumor-infiltrating lymphocytes (TILs) have a higher probability of pathologic complete response, even in luminal/human epidermal growth factor 2 (HER2)-negative breast cancer. We compared TIL levels and the 21-gene recurrence score (RS) in estrogen receptor (ER)-positive/HER2-negative breast cancer. METHODS: We evaluated the percentage of stromal TILs in 198 ER-positive/HER2-negative patients in whom RS was obtained by examining slides of surgical specimens by standardized methodology proposed by the international TIL Working Group. TIL levels were categorized as high (>/= 60%), intermediate (11-59%), or low (</= 10%). All tumors were treatment-naive. RESULTS: Ninety-seven (49.0%), 88 (44.4%), and 13 patients (6.6%) had low, intermediate, and high TIL levels, respectively. There was a significant but weak correlation between continuous RS and continuous TIL levels (Pearson's R = 0.201, p = 0.004). The mean RS was significantly highest in high TIL tumors (17.8 +/- 10.7 in low TIL tumors, 19.4 +/- 8.7 in intermediate TIL tumors, and 26.2 +/- 8.2 in high TIL tumors; p = 0.014). However, when we compared categorized RS and TIL levels, we found that tumors with high TIL levels tended to have higher RS (>/= 26) but it was not significant (p = 0.155). Furthermore, multivariate analysis revealed that high RS was not an independent factor associated with high TIL levels. Chemo-endocrine therapy was more frequently performed among patients with high TILs and less frequently among those with low or intermediate TILs (p < 0.001). CONCLUSIONS: Despite of a weak correlation between continuous TIL levels and RS, we found that tumors with high TIL levels tended to have a higher RS in ER-positive/HER2-negative breast cancer. Further study is warranted considering the clinical outcomes.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleComparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorSung Gwe Ahn-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorSoon June Bae-
dc.contributor.googleauthorChanik Yoon-
dc.contributor.googleauthorHak Woo Lee-
dc.contributor.googleauthorJoon Jeong-
dc.identifier.doi10.1186/s12885-018-4228-6-
dc.contributor.localIdA05345-
dc.contributor.localIdA02231-
dc.contributor.localIdA05369-
dc.contributor.localIdA05015-
dc.contributor.localIdA03727-
dc.contributor.localIdA04001-
dc.relation.journalcodeJ00351-
dc.identifier.eissn1471-2407-
dc.identifier.pmid29573739-
dc.subject.keyword21-gene recurrence score-
dc.subject.keywordBreast cancer-
dc.subject.keywordTumor-infiltrating lymphocytes-
dc.contributor.alternativeNameBae, Soong June-
dc.contributor.alternativeNameAhn, Sung Gwe-
dc.contributor.alternativeNameYoon, Changik-
dc.contributor.alternativeNameLee, Hak Woo-
dc.contributor.alternativeNameJeong, Joon-
dc.contributor.alternativeNameCha, Yoon Jin-
dc.contributor.affiliatedAuthorBae, Soong June-
dc.contributor.affiliatedAuthorAhn, Sung Gwe-
dc.contributor.affiliatedAuthorYoon, Changik-
dc.contributor.affiliatedAuthorLee, Hak Woo-
dc.contributor.affiliatedAuthorJeong, Joon-
dc.contributor.affiliatedAuthorCha, Yoon Jin-
dc.citation.volume18-
dc.citation.number1-
dc.citation.startPage320-
dc.identifier.bibliographicCitationBMC CANCER, Vol.18(1) : 320, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.