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Age- and Sex-Specific Differences as Predictors of Surgical Remission Among Patients With Acromegaly

DC FieldValueLanguage
dc.contributor.author구철룡-
dc.contributor.author김선호-
dc.contributor.author김의현-
dc.contributor.author문주형-
dc.contributor.author박세희-
dc.contributor.author이은직-
dc.date.accessioned2018-08-28T17:27:15Z-
dc.date.available2018-08-28T17:27:15Z-
dc.date.issued2018-
dc.identifier.issn0021-972X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162629-
dc.description.abstractContext: Sex and age are factors conferring resistance to medical treatment in patients with acromegaly. However, their impact on outcomes of transsphenoidal-selective adenomectomy (TSA) has not been evaluated. Objective: To analyze age- and sex-related differences concerning surgical outcomes of growth hormone (GH)-secreting pituitary adenomas. Design: Retrospective. Setting: Single-center tertiary hospital. Participants: Patients with acromegaly (n = 463) who underwent TSA between January 2000 and July 2014. Intervention: TSA. Main Outcome Measurements: Tumor characteristics and surgical outcomes. Results: Sex differences existed in the baseline insulinlike growth factor-1 levels and the mean tumor size. Overall, surgical remission rates were 89.7% and 76.5% in male and female patients, respectively (P < 0.001). Total tumor tissue resection was performed in 92.6% and 85.8% of male and female participants, respectively (P = 0.021). Premenopausal women had a higher proportion of pituitary adenoma with cavernous sinus invasion than did men aged <50 years (35.3% vs 21.7%, P = 0.007). In immediate postoperative, 75-g oral glucose tolerance tests, fewer premenopausal women reached <1 ng/dL nadir GH levels than did men aged <50 years (59.9% vs 87.7%, P < 0.001). Surgical results were similar in both sexes among older patients (>/=50 years). However, premenopausal women had significantly lower long-term remission rates than did men aged <50 years (69.3% vs 88.0%, P < 0.001). Conclusion: Premenopausal women with acromegaly tend to have larger tumors, more aggressive tumor types, and lower remission rates than do men. However, further studies on the clinical implications are needed.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherEndocrine Society-
dc.relation.isPartOfJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcromegaly/blood/etiology/*surgery-
dc.subject.MESHAdenoma/blood/complications/pathology/*surgery-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHFemale-
dc.subject.MESHGrowth Hormone-Secreting Pituitary Adenoma/blood/complications/pathology/*surgery-
dc.subject.MESHHuman Growth Hormone/blood/secretion-
dc.subject.MESHHumans-
dc.subject.MESHInsulin-Like Growth Factor I/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHPremenopause-
dc.subject.MESHPrognosis-
dc.subject.MESHRemission Induction-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSex Characteristics-
dc.subject.MESHSex Factors-
dc.subject.MESHTreatment Outcome-
dc.titleAge- and Sex-Specific Differences as Predictors of Surgical Remission Among Patients With Acromegaly-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSe Hee Park-
dc.contributor.googleauthorCheol Ryong Ku-
dc.contributor.googleauthorJu Hyung Moon-
dc.contributor.googleauthorEui Hyun Kim-
dc.contributor.googleauthorSun Ho Kim-
dc.contributor.googleauthorEun Jig Lee-
dc.identifier.doi10.1210/jc.2017-01844-
dc.contributor.localIdA00201-
dc.contributor.localIdA00560-
dc.contributor.localIdA00837-
dc.contributor.localIdA01383-
dc.contributor.localIdA01525-
dc.contributor.localIdA03050-
dc.relation.journalcodeJ01318-
dc.identifier.eissn1945-7197-
dc.identifier.pmid29272449-
dc.identifier.urlhttps://academic.oup.com/jcem/article/103/3/909/4764024-
dc.contributor.alternativeNameKu, Cheol Ryong-
dc.contributor.alternativeNameKim, Sun Ho-
dc.contributor.alternativeNameKim, Eui Hyun-
dc.contributor.alternativeNameMoon, Ju Hyung-
dc.contributor.alternativeNamePark, Se Hee-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.affiliatedAuthorKu, Cheol Ryong-
dc.contributor.affiliatedAuthorKim, Sun Ho-
dc.contributor.affiliatedAuthorKim, Eui Hyun-
dc.contributor.affiliatedAuthorMoon, Ju Hyung-
dc.contributor.affiliatedAuthorPark, Se Hee-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.citation.volume103-
dc.citation.number3-
dc.citation.startPage909-
dc.citation.endPage916-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.103(3) : 909-916, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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