Cited 17 times in
Development of a radionuclide-labeled monoclonal anti-CD55 antibody with theranostic potential in pleural metastatic lung cancer
DC Field | Value | Language |
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dc.contributor.author | 김락균 | - |
dc.date.accessioned | 2018-08-28T17:25:34Z | - |
dc.date.available | 2018-08-28T17:25:34Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162589 | - |
dc.description.abstract | Decay-accelerating factor (CD55 or DAF) inhibits complement-dependent cytotoxicity. We determined that CD55 is overexpressed in 76.47% of human non-small cell lung cancer tissue specimens. We therefore developed a lutetium-177-labeled chimeric monoclonal antibody against CD55. CD55-specific single-chain variable fragment (scFv) was selected from a naive chicken scFv phage-display library, converted to IgG, and radiolabeled with lutetium-177 to generate a (177)Lu-anti-CD55 antibody. We then charaterized the biodistribution of this antibody in a mouse model of pleural metastatic lung cancer. The (177)Lu-anti-CD55 antibody was primarily retained in tumor tissue rather than normal tissue. Treatment of the mice with (177)Lu-anti-CD55 reduced the growth of lung tumors and improved median survival in vivo by two-fold compared to controls. Finally, (177)Lu-anti-CD55 also enhanced the antitumor activity of cisplatin both in vitro and in vivo. These data suggest (177)Lu-anti-CD55 antibody is a promising theranostic agent for pleural metastatic lung cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Development of a radionuclide-labeled monoclonal anti-CD55 antibody with theranostic potential in pleural metastatic lung cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | So Hee Dho | - |
dc.contributor.googleauthor | Soo Yong Kim | - |
dc.contributor.googleauthor | Chaeuk Chung | - |
dc.contributor.googleauthor | Eun Ha Cho | - |
dc.contributor.googleauthor | So-Young Lee | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Lark Kyun Kim | - |
dc.contributor.googleauthor | Sung-Won Min | - |
dc.contributor.googleauthor | Jichul Lee | - |
dc.contributor.googleauthor | Sung Hee Jung | - |
dc.contributor.googleauthor | Jae Cheong Lim | - |
dc.identifier.doi | 10.1038/s41598-018-27355-8 | - |
dc.contributor.localId | A04520 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 29895866 | - |
dc.contributor.alternativeName | Kim, Lark Kyun | - |
dc.contributor.affiliatedAuthor | Kim, Lark Kyun | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 8960 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.8(1) : 8960, 2018 | - |
dc.identifier.rimsid | 60169 | - |
dc.type.rims | ART | - |
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