Cited 9 times in
Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients
DC Field | Value | Language |
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dc.contributor.author | 박광호 | - |
dc.contributor.author | 최유리 | - |
dc.contributor.author | 허종기 | - |
dc.date.accessioned | 2018-08-28T17:25:25Z | - |
dc.date.available | 2018-08-28T17:25:25Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2234-7550 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162586 | - |
dc.description.abstract | Objectives: The aim of this study was to reveal how collagenases (matrix metalloproteinase [MMP]-1, 8, 13) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are expressed in immunohistochemistry of retrodiscal tissue in temporomandibular joint disorder patients. Materials and Methods: This study was conducted on 39 patients who underwent discoplasty or discectomy. Immunohistochemical staining was undertaken and expression levels of MMP-1, 8, 13, and TIMP-1 were evaluated. The status of internal derangement of disc, osteoarthritis, and joint effusion were analyzed using magnetic resonance imaging (MRI). Disc status observed during operation was also categorized. Results: The more severe disc derangement was observed on MRI, the more increased expression of MMPs and TIMP-1 appeared. Regarding MMP-13 expression, 86.7% of late-stage disc displacement patients showed grade II or III. Expression level of MMPs or TIMP was not statistically significant associated with joint effusion level. In perforation and/or adhesion groups, all patients showed grade II or III expression of MMP-13. Once perforation occurred, MMP-13 showed increased expression with statistical significance. Conclusion: MMP-1 and MMP-13 expression seem to be related to progression of osteoarthritis whereas MMP-8 does not seem to have a specific role with regard to temporomandibular joint disorders. TIMP-1 is considered to be partly related to internal derangement rather than osteoarthritis, but it is not significant. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한구강악안면외과학회 | - |
dc.relation.isPartOf | Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral and Maxillofacial Surgery | - |
dc.contributor.googleauthor | Won Gyung Gho | - |
dc.contributor.googleauthor | Yuri Choi | - |
dc.contributor.googleauthor | Kwang-Ho Park | - |
dc.contributor.googleauthor | Jong-Ki Huh | - |
dc.identifier.doi | 10.5125/jkaoms.2018.44.3.120 | - |
dc.contributor.localId | A01435 | - |
dc.contributor.localId | A05055 | - |
dc.contributor.localId | A04365 | - |
dc.relation.journalcode | J01806 | - |
dc.identifier.eissn | 2234-5930 | - |
dc.identifier.pmid | 29963493 | - |
dc.subject.keyword | Collagenases | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Matrix metalloproteinase | - |
dc.subject.keyword | Temporomandibular joint disorders | - |
dc.subject.keyword | Tissue inhibitor of metalloproteinase | - |
dc.contributor.alternativeName | Park, Kwang Ho | - |
dc.contributor.alternativeName | Choi, Yuri | - |
dc.contributor.alternativeName | Huh, Jong Ki | - |
dc.contributor.affiliatedAuthor | Park, Kwang Ho | - |
dc.contributor.affiliatedAuthor | Choi, Yuri | - |
dc.contributor.affiliatedAuthor | Huh, Jong Ki | - |
dc.citation.volume | 44 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 120 | - |
dc.citation.endPage | 127 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.44(3) : 120-127, 2018 | - |
dc.identifier.rimsid | 60166 | - |
dc.type.rims | ART | - |
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