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Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: results from the Asia Pacific Cohort Studies Collaboration

DC FieldValueLanguage
dc.contributor.author김현창-
dc.date.accessioned2018-08-28T17:24:27Z-
dc.date.available2018-08-28T17:24:27Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162567-
dc.description.abstractOBJECTIVE: To assess the relationship between risk factor clusters and cardiovascular disease (CVD) incidence in Asian and Caucasian populations and to estimate the burden of CVD attributable to each cluster. SETTING: Asia Pacific Cohort Studies Collaboration. PARTICIPANTS: Individual participant data from 34 population-based cohorts, involving 314 024 participants without a history of CVD at baseline. OUTCOME MEASURES: Clusters were 11 possible combinations of four individual risk factors (current smoking, overweight, blood pressure (BP) and total cholesterol). Cox regression models were used to obtain adjusted HRs and 95% CIs for CVD associated with individual risk factors and risk factor clusters. Population-attributable fractions (PAFs) were calculated. RESULTS: During a mean follow-up of 7 years, 6203 CVD events were recorded. The ranking of HRs and PAFs was similar for Australia and New Zealand (ANZ) and Asia; clusters including BP consistently showed the highest HRs and PAFs. The BP-smoking cluster had the highest HR for people with two risk factors: 4.13 (3.56 to 4.80) for Asia and 3.07 (2.23 to 4.23) for ANZ. Corresponding PAFs were 24% and 11%, respectively. For individuals with three risk factors, the BP-smoking-cholesterol cluster had the highest HR (4.67 (3.92 to 5.57) for Asia and 3.49 (2.69 to 4.53) for ANZ). Corresponding PAFs were 13% and 10%. CONCLUSIONS: Risk factor clusters act similarly on CVD risk in Asian and Caucasian populations. Clusters including elevated BP were associated with the highest excess risk of CVD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBMJ Publishing Group Ltd-
dc.relation.isPartOfBMJ OPEN-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: results from the Asia Pacific Cohort Studies Collaboration-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorSanne A E Peters-
dc.contributor.googleauthorXin Wang-
dc.contributor.googleauthorTai-Hing Lam-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorSuzanne Ho-
dc.contributor.googleauthorToshiharu Ninomiya-
dc.contributor.googleauthorMatthew Knuiman-
dc.contributor.googleauthorIlonca Vaartjes-
dc.contributor.googleauthorMichael L Bots-
dc.contributor.googleauthorMark Woodward-
dc.identifier.doi10.1136/bmjopen-2017-019335-
dc.contributor.localIdA01142-
dc.relation.journalcodeJ00380-
dc.identifier.eissn2044-6055-
dc.identifier.pmid29511013-
dc.subject.keywordepidemiology-
dc.subject.keywordmyocardial infarction-
dc.subject.keywordpreventive medicine-
dc.subject.keywordstroke-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.citation.volume8-
dc.citation.number3-
dc.citation.startPagee019335-
dc.identifier.bibliographicCitationBMJ OPEN, Vol.8(3) : e019335, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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