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Impact of Early Salvage Androgen Deprivation Therapy in Localized Prostate Cancer after Radical Prostatectomy: A Propensity Score Matched Analysis

DC Field Value Language
dc.contributor.author고동훈-
dc.contributor.author나군호-
dc.contributor.author박재원-
dc.contributor.author장원식-
dc.contributor.author최영득-
dc.contributor.author함원식-
dc.contributor.author홍성준-
dc.date.accessioned2018-08-28T17:23:49Z-
dc.date.available2018-08-28T17:23:49Z-
dc.date.issued2018-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162558-
dc.description.abstractPURPOSE: Androgen deprivation therapy (ADT) is used as a salvage treatment for men with biochemical recurrence (BCR) of prostate cancer (PCa) following initial radical prostatectomy (RP). The optimal time at which to begin salvage ADT (sADT) remains controversial. In this retrospective study, we evaluated the efficacy of initiating sADT in patients before prostate-specific antigen (PSA) values met the clinical definition of BCR. MATERIALS AND METHODS: We identified 484 PCa patients who received sADT for BCR after RP. Median follow-up was 82 months. Propensity score matching was performed based on preoperative PSA level, pathologic T stage, and Gleason score. Patients were assigned to two groups of 169 patients each, based on PSA levels at the time of sADT: Group A (without meeting of the definition of BCR) and Group B (after BCR). Kaplan-Meier survival analyses and Cox regression analyses were performed. RESULTS: The median PSA level at sADT initiation was 0.12 ng/mL in group A and 0.42 ng/mL in group B. Kaplan-Meier analyses showed that group A had favorable disease progression-free survival (DPFS) and distant metastasis-free survival (DMFS), but did not have better cancer-specific survival (CSS) than group B. In subgroup analyses, group A showed better CSS rates in the non-organ confined PCa group. In Cox regression analyses, early sADT was associated significantly with DPFS and DMFS rates, however, did not correlate with CSS (p=0.107). CONCLUSION: Early sADT after RP improved DPFS and DMFS. Furthermore, early sADT patients demonstrated better CSS in non-organ confined PCa.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAndrogen Antagonists/*therapeutic use-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHLocal/pathology/surgery Neoplasm Recurrence-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPropensity Score-
dc.subject.MESHProstate-Specific Antigen-
dc.subject.MESHProstatectomy/*methods-
dc.subject.MESHProstatic Neoplasms/mortality/pathology/*therapy-
dc.subject.MESHRegression Analysis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSalvage Therapy/*methods-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.titleImpact of Early Salvage Androgen Deprivation Therapy in Localized Prostate Cancer after Radical Prostatectomy: A Propensity Score Matched Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Urology-
dc.contributor.googleauthorJae Won Park-
dc.contributor.googleauthorWon Sik Jang-
dc.contributor.googleauthorDong Hoon Koh-
dc.contributor.googleauthorWon Sik Ham-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorSung Joon Hong-
dc.contributor.googleauthorYoung Deuk Choi-
dc.identifier.doi10.3349/ymj.2018.59.5.580-
dc.contributor.localIdA05450-
dc.contributor.localIdA01227-
dc.contributor.localIdA04748-
dc.contributor.localIdA05268-
dc.contributor.localIdA04111-
dc.contributor.localIdA04337-
dc.contributor.localIdA04402-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid29869455-
dc.subject.keywordRadical prostatectomy-
dc.subject.keywordandrogen deprivation therapy-
dc.subject.keywordprostate specific antigen-
dc.subject.keywordsalvage therapy-
dc.contributor.alternativeNameKoh, Dong Hoon-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.alternativeNamePark, Jae Won-
dc.contributor.alternativeNameJang, Won Sik-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameHam, Won Sik-
dc.contributor.alternativeNameHong, Sung Joon-
dc.contributor.affiliatedAuthorKoh, Dong Hoon-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.contributor.affiliatedAuthorPark, Jae Won-
dc.contributor.affiliatedAuthorJang, Won Sik-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorHam, Won Sik-
dc.contributor.affiliatedAuthorHong, Sung Joon-
dc.citation.volume59-
dc.citation.number5-
dc.citation.startPage580-
dc.citation.endPage587-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.59(5) : 580-587, 2018-
dc.identifier.rimsid60139-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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