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Effects of Perianal Involvement on Clinical Outcomes in Crohn's Disease over 10 Years

DC FieldValueLanguage
dc.contributor.author김원호-
dc.contributor.author김태일-
dc.contributor.author박수정-
dc.contributor.author천재희-
dc.date.accessioned2018-08-28T17:23:31Z-
dc.date.available2018-08-28T17:23:31Z-
dc.date.issued2018-
dc.identifier.issn1976-2283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162554-
dc.description.abstractBackground/Aims: There was the assumption that Crohn's disease (CD) patients with perianal lesions might have different clinical courses compared to those without. However, quantifiable data comparing the long-term outcomes between the two groups are scarce. Methods: We retrospectively reviewed 221 consecutive patients newly diagnosed with CD and registered at the IBD clinic of Severance Hospital, in Seoul, Korea, between January 1990 and October 2005. We compared patients with perianal CD (PCD) and non-perianal CD (NPCD) in terms of clinical outcomes over 10 years. Results: PCD progressed more frequently from inflammatory to complicated behavior than NPCD. Moreover, corticosteroids were prescribed in 102 patients with PCD and only 57 with NPCD (82.9% vs 58.2%, p0.001), immunosuppressants in 89 and 42 (72.4% vs 42.9%, p0.001), and anti-tumor necrosis factor alpha (TNF-alpha) in 37 and 12 (30.1% vs 12.2%, p=0.002). Cumulative hospitalization rates were 82.1% in PCD and 72.4% in NPCD (p=0.086), and surgical intervention rates were 39.8% and 51.0%, respectively (p=0.097). Conclusions: Patients with PCD were more likely than those with NPCD to be administered corticosteroids, immunosuppressants, and anti-TNF-alpha. However, there is no significant difference in the cumulative rates of surgical interventions or hospitalizations.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherEditorial Office of Gut and Liver-
dc.relation.isPartOfGut and Liver-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of Perianal Involvement on Clinical Outcomes in Crohn's Disease over 10 Years-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJin Young Yoon-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorSoo Jung Park-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.identifier.doi10.5009/gnl17275-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA01539-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ00954-
dc.identifier.eissn2005-1212-
dc.identifier.pmid29108399-
dc.subject.keywordCrohn disease-
dc.subject.keywordOutcomes-
dc.subject.keywordPerianal lesion-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Soo Jung-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorPark, Soo Jung-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.volume12-
dc.citation.number3-
dc.citation.startPage297-
dc.citation.endPage305-
dc.identifier.bibliographicCitationGut and Liver, Vol.12(3) : 297-305, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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