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Teriparatide therapy for severe, refractory osteoradionecrosis of the jaw

DC Field Value Language
dc.contributor.author이유미-
dc.contributor.author차용훈-
dc.contributor.author차인호-
dc.contributor.author홍남기-
dc.date.accessioned2018-08-28T17:22:40Z-
dc.date.available2018-08-28T17:22:40Z-
dc.date.issued2018-
dc.identifier.issn0937-941X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162539-
dc.description.abstractAlthough osteoradionecrosis (ORN) is a serious complication of craniofacial radiotherapy, the current management methods remain suboptimal. Teriparatide (TPTD), a recombinant human parathyroid hormone (1-34), has shown beneficial effects on osseous regeneration in medication-related osteonecrosis of the jaw or periodontitis. However, TPTD therapy in irradiated bones has not been indicated yet because of the theoretical risk of osteosarcoma seen in rat models. Hence, we first report here two patients with tongue cancer with late-emerging ORN who were successfully treated with TPTD for 4-6 months with serum calcium and vitamin D supplementation. In contrast to the usual progress of ORN, the bone defect regenerated well and bone turnover markers including serum C-terminal telopeptide of type 1 collagen and osteocalcin were restored with TPTD therapy. Our experience might suggest that TPTD therapy with careful monitoring can provide an effective treatment option for patients with ORN in select refractory cases, with the benefits outweighing the potential risks.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfOSTEOPOROSIS INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTeriparatide therapy for severe, refractory osteoradionecrosis of the jaw-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorY H Cha-
dc.contributor.googleauthorN Hong-
dc.contributor.googleauthorY Rhee-
dc.contributor.googleauthorI-H Cha-
dc.identifier.doi10.1007/s00198-017-4343-2-
dc.contributor.localIdA03012-
dc.contributor.localIdA04000-
dc.contributor.localIdA04002-
dc.contributor.localIdA04388-
dc.relation.journalcodeJ02451-
dc.identifier.eissn1433-2965-
dc.identifier.pmid29249017-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00198-017-4343-2-
dc.subject.keywordOsteoradionecrosis-
dc.subject.keywordRadiation therapy-
dc.subject.keywordRecombinant human parathyroid hormone (1-34)-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameCha, Yong Hoon-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.alternativeNameHong, Nam Ki-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorCha, Yong Hoon-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.contributor.affiliatedAuthorHong, Namki-
dc.citation.volume29-
dc.citation.number4-
dc.citation.startPage987-
dc.citation.endPage992-
dc.identifier.bibliographicCitationOSTEOPOROSIS INTERNATIONAL, Vol.29(4) : 987-992, 2018-
dc.identifier.rimsid60120-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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