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Impaired White Matter Integrity and Social Cognition in High-Function Autism: Diffusion Tensor Imaging Study

Authors
 Woo Young Im  ;  Ji Hye Ha  ;  Eun Joo Kim  ;  Keun-Ah Cheon  ;  Jaeil Cho  ;  Dong-Ho Song 
Citation
 Psychiatry Investigation, Vol.15(3) : 292-299, 2018 
Journal Title
 Psychiatry Investigation 
ISSN
 1738-3684 
Issue Date
2018
Keywords
Brain network ; Diffusion tensor imaging ; Functional connectivity ; High-function autism ; White matter
Abstract
OBJECTIVE: It is known that many of the cognitive and social deficits associated with autism can arise from abnormal functional connectivity between brain networks. This aberrant functional connectivity in autism spectrum disorders (ASD) can be explained by impaired integrity of white matter tracts that link distant regions of the networks. METHODS: We investigated white matter in 9 children with high-function autism (HFA) compared to 13 typically developing controls using diffusion tensor imaging (DTI). The aim of this research is to provide supporting evidence for abnormalities in neural connectivity as an underlying pathophysiology of the main characteristics of ASD. RESULTS: We found impairment of neural connectivity, mainly in association fiber tracts as evidenced by decreased fractional anisotropy (FA), the index of white matter integrity, of these tracts. Among them, inferior fronto-occipital fasciculus (IFOF) had a significant relationship with ADI-R score. The inferior longitudinal fasciculus (ILF) and superior longitudinal fasciculus (SLF) also showed decreased FA. Decreased FA of ILF and SLF had negative correlations with scores of social interaction. CONCLUSION: These findings suggest that widespread abnormalities in association fiber tracts may contribute to both core and associated symptoms of ASD.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162517
Files in This Item:
T201801820.pdf Download
DOI
10.30773/pi.2017.08.15
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
김은주(Kim, Eun Joo)
송동호(Song, Dong Ho) ORCID logo https://orcid.org/0000-0002-9647-3130
천근아(Cheon, Keun Ah)
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