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Cited 13 times in

Ejection fraction as related to basic components in the left and right ventricular volume domains

DC FieldValueLanguage
dc.contributor.author류병원-
dc.date.accessioned2018-08-28T17:21:29Z-
dc.date.available2018-08-28T17:21:29Z-
dc.date.issued2018-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162514-
dc.description.abstractBACKGROUND: Ejection fraction (EF) is commonly applied as a clinically relevant metric to assess ventricular function. The numerical value of EF depends on the interplay between end-systolic volume (ESV) and end-diastolic volume (EDV). Remarkably, the relative impact of the two constitutive components on EF received little attention. METHODS: Three patient groups not using beta-blockers were analyzed for a robust investigation into the relative contribution of ESV and EDV when assessing EF: cardiac patients (N=155) with left ventricular (LV) data obtained by biplane ventriculography, near-normals (N=276) by gated SPECT investigation, and an MRI-based post Fallot repair study including right ventricular (RV) data (N=124), besides LV. We compared various routes to evaluate EF via linear and several types of nonlinear regression with ESV as independent variable. Advanced statistics was applied to evaluate sex-specific differences. RESULTS: In all cases ESV emerges as the dominant component of EF, with less (P<0.0001) impact of EDV. The relationship for EF versus ESV is nonlinear (P<0.0001), and similar for both sexes. A linear approach may be inadequate and generate erroneous statistical outcomes when comparing subgroups of patients. CONCLUSIONS: Values for EF primarily depend on ESV, both for LV and RV. This relationship is essentially nonlinear, and similar for both sexes. A logarithmic approximation is convenient and often acceptable. However, application of linear regression for EF vs ESV may lead to incorrect conclusions, particularly when comparing males and females.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEjection fraction as related to basic components in the left and right ventricular volume domains-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentOthers-
dc.contributor.googleauthorPeter L M Kerkhof-
dc.contributor.googleauthorPeter M van de Ven-
dc.contributor.googleauthorByungwon Yoo-
dc.contributor.googleauthorRichard A Peace-
dc.contributor.googleauthorGuy R Heyndrickx-
dc.contributor.googleauthorNeal Handly-
dc.identifier.doi10.1016/j.ijcard.2017.09.019-
dc.contributor.localIdA05470-
dc.relation.journalcodeJ01093-
dc.identifier.eissn1874-1754-
dc.identifier.pmid29425548-
dc.subject.keywordEjection fraction-
dc.subject.keywordEnd-systolic volume-
dc.subject.keywordNonlinear regression-
dc.subject.keywordRemodeling-
dc.subject.keywordRight ventricle-
dc.subject.keywordSex-specific analysis-
dc.subject.keywordStatistics-
dc.subject.keywordVentricular volume regulation-
dc.contributor.alternativeNameYoo, Byungwon-
dc.contributor.affiliatedAuthorYoo, Byungwon-
dc.citation.volume255-
dc.citation.startPage105-
dc.citation.endPage110-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.255 : 105-110, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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