Cited 21 times in
Efficacy of Palonosetron-Dexamethasone Combination Versus Palonosetron Alone for Preventing Nausea and Vomiting Related to Opioid-Based Analgesia: A Prospective, Randomized, Double-blind Trial
DC Field | Value | Language |
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dc.contributor.author | 김도형 | - |
dc.contributor.author | 김승현 | - |
dc.contributor.author | 신서경 | - |
dc.contributor.author | 오영준 | - |
dc.contributor.author | 최용선 | - |
dc.date.accessioned | 2018-08-28T17:21:25Z | - |
dc.date.available | 2018-08-28T17:21:25Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162513 | - |
dc.description.abstract | Background: The efficacy of dexamethasone plus palonosetron for postoperative nausea and vomiting (PONV) prophylaxis is not firmly established. This randomized, double-blind, controlled study evaluated whether the combination was superior to palonosetron alone in preventing PONV in patients receiving intravenous patient-controlled analgesia (IV-PCA) after upper extremity surgery. Methods: A total of 202 patients undergoing upper extremity surgery were randomly assigned to group P (palonosetron alone) or group PD (palonosetron plus dexamethasone). Group P patients received palonosetron 0.075 mg and normal saline 1.6 mL; group PD patients received palonosetron 0.075 mg and dexamethasone 8 mg. In both groups, palonosetron was added to the IV-PCA opioid infusion, which was continued for 48 h postoperatively. Incidence and severity of nausea, incidence of vomiting, rescue antiemetic requirements, pain intensity, and rescue analgesic requirements were evaluated for 72 h postoperatively. Quality of recovery was assessed using the quality of recovery-15 (QoR-15) questionnaire. Results: The incidence of PONV was significantly lower in group PD than in group P at 0-48 h postoperatively (61.5% vs 77.1%; p = 0.019). Severity of nausea at 0-6 h postoperatively was significantly less in group PD compared with group P (none/mild/moderate/severe: 49/22/15/10 vs. 36/16/25/19, p = 0.008). The incidence of vomiting and rescue antiemetic requirements were similar between groups. Pain intensity was significantly less in group PD than in group P at 0-48 h and 48-72 h postoperatively. Global QoR-15 was similar 24 h postoperatively between groups. Conclusions: Dexamethasone-palonosetron combination therapy reduced PONV incidence and postoperative pain in patients receiving opioid-based analgesia after upper extremity surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Efficacy of Palonosetron-Dexamethasone Combination Versus Palonosetron Alone for Preventing Nausea and Vomiting Related to Opioid-Based Analgesia: A Prospective, Randomized, Double-blind Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Eunah Cho | - |
dc.contributor.googleauthor | Do-Hyeong Kim | - |
dc.contributor.googleauthor | Seokyung Shin | - |
dc.contributor.googleauthor | Seung Hyun Kim | - |
dc.contributor.googleauthor | Young Jun Oh | - |
dc.contributor.googleauthor | Yong Seon Choi | - |
dc.identifier.doi | 10.7150/ijms.24230 | - |
dc.contributor.localId | A00390 | - |
dc.contributor.localId | A05098 | - |
dc.contributor.localId | A02109 | - |
dc.contributor.localId | A02389 | - |
dc.contributor.localId | A04119 | - |
dc.relation.journalcode | J02917 | - |
dc.identifier.eissn | 1449-1907 | - |
dc.identifier.pmid | 30013436 | - |
dc.subject.keyword | Dexamethasone | - |
dc.subject.keyword | Palonosetron | - |
dc.subject.keyword | Postoperative nausea and vomiting | - |
dc.contributor.alternativeName | Kim, Do Hyeong | - |
dc.contributor.alternativeName | Kim, Seung Hyun | - |
dc.contributor.alternativeName | Shin, Seo Kyung | - |
dc.contributor.alternativeName | Oh, Young Jun | - |
dc.contributor.alternativeName | Choi, Yong Seon | - |
dc.contributor.affiliatedAuthor | Kim, Do Hyeong | - |
dc.contributor.affiliatedAuthor | Kim, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Shin, Seo Kyung | - |
dc.contributor.affiliatedAuthor | Oh, Young Jun | - |
dc.contributor.affiliatedAuthor | Choi, Yong Seon | - |
dc.citation.volume | 15 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 961 | - |
dc.citation.endPage | 968 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, Vol.15(10) : 961-968, 2018 | - |
dc.identifier.rimsid | 60094 | - |
dc.type.rims | ART | - |
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