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Force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma

DC Field Value Language
dc.contributor.author강석구-
dc.date.accessioned2018-08-28T17:21:16Z-
dc.date.available2018-08-28T17:21:16Z-
dc.date.issued2018-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162509-
dc.description.abstractIn carcinoma, cancer-associated fibroblasts participate in force-mediated extracellular matrix (ECM) remodeling, consequently leading to invasion of cancer cells. Likewise, the ECM remodeling actively occurs in glioblastoma (GBM) and the consequent microenvironmental stiffness is strongly linked to migration behavior of GBM cells. However, in GBM the stromal cells responsible for force-mediated ECM remodeling remain unidentified. We show that tumor-associated mesenchymal stem-like cells (tMSLCs) provide a proinvasive matrix condition in GBM by force-mediated ECM remodeling. Importantly, CCL2-mediated Janus kinase 1 (JAK1) activation increased phosphorylation of myosin light chain 2 in tMSLCs and led to collagen assembly and actomyosin contractility. Collectively, our findings implicate tMSLCs as stromal cells providing force-mediated proinvasive ECM remodeling in the GBM microenvironment, and reminiscent of fibroblasts in carcinoma. [BMB Reports 2018; 51(4): 182-187].-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfBMB REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleForce-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurosurgery-
dc.contributor.googleauthorEun-Jung Lim-
dc.contributor.googleauthorYongjoon Suh-
dc.contributor.googleauthorSeungmo Kim-
dc.contributor.googleauthorSeok-Gu Kang-
dc.contributor.googleauthorSu-Jae Lee-
dc.identifier.doi10.5483/BMBRep.2018.51.4.185-
dc.contributor.localIdA00036-
dc.relation.journalcodeJ00348-
dc.identifier.eissn1976-670X-
dc.identifier.pmid29301607-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.affiliatedAuthorKang, Seok Gu-
dc.citation.volume51-
dc.citation.number4-
dc.citation.startPage182-
dc.citation.endPage187-
dc.identifier.bibliographicCitationBMB REPORTS, Vol.51(4) : 182-187, 2018-
dc.identifier.rimsid60090-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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