Cited 24 times in
Potential miRNA-target interactions for the screening of gastric carcinoma development in gastric adenoma/dysplasia
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dc.contributor.author | 이용찬 | - |
dc.date.accessioned | 2018-08-28T17:21:01Z | - |
dc.date.available | 2018-08-28T17:21:01Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162502 | - |
dc.description.abstract | Although miRNA markers have been identified for the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism are still not fully understood. Moreover, some gastric adenoma/dysplasia may progress to GAC. In this study, the miRNA expression profiles in normal and paired low-/high-grade dysplasia were analyzed using Affymetrix Gene-Chip miRNA arrays. Of the total 2578 mature miRNA probe sets, ~1600 showed positive signals when the between normal and paired low-/high-grade dysplasia were compared. To verify the miRNA expression, qRT-PCR analysis was performed to quantify the expression of altered miRNAs between normal and paired low-/high-grade dysplasia. The analysis revealed that hsa-miR-421, hsa-miR-29b-1-5p, and hsa-miR-27b-5p were overexpressed in gastric low-/high-grade dysplasia and that based on these miRNA-target interactions, FBXO11 and CREBZF could be considered convincing markers for gastric cancer (GC) progression. Thus, we identified three miRNAs (hsa-miR-421, hsa-miR-29b-1-5p, and hsa-miR-27b-5p) with two mRNAs (FBXO11 and CREBZF) that might play an important role in the GC development from premalignant adenomas. Furthermore, these two target mRNAs and three miRNAs were predicted to be potential biomarkers for the progression of GC by miRNA-target interaction analysis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Potential miRNA-target interactions for the screening of gastric carcinoma development in gastric adenoma/dysplasia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Yu Jin Kim | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Sang Woo Kim | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.identifier.doi | 10.7150/ijms.24061 | - |
dc.contributor.localId | A02988 | - |
dc.relation.journalcode | J02917 | - |
dc.identifier.eissn | 1449-1907 | - |
dc.identifier.pmid | 29725252 | - |
dc.subject.keyword | gastric adenocarcinoma | - |
dc.subject.keyword | hsa-miR-27b-5p | - |
dc.subject.keyword | hsa-miR-29b-1-5p | - |
dc.subject.keyword | hsa-miR-421 | - |
dc.subject.keyword | microRNA | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 610 | - |
dc.citation.endPage | 616 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, Vol.15(6) : 610-616, 2018 | - |
dc.identifier.rimsid | 60083 | - |
dc.type.rims | ART | - |
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