Cited 12 times in
Differences in Therapeutic Responses and Factors Affecting Post-Stroke Depression at a Later Stage According to Baseline Depression
DC Field | Value | Language |
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dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2018-08-28T17:21:00Z | - |
dc.date.available | 2018-08-28T17:21:00Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2287-6391 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162501 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual's mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. METHODS: This study involved a post hoc analysis of data from EMOTION (ClinicalTrials.gov NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke. Participants were classified into the Baseline-Blue (patients with baseline depression at the time of randomization, defined per the Montgomery-Asberg Depression Rating Scale [MADRS] >/=8) or the Baseline-Pink groups (patients without baseline depression). We compared the efficacy of escitalopram and predictors of 3-month PSD (MADRS >/=8) between these groups. RESULTS: There were 203 Baseline-Pink and 275 Baseline-Blue patients. The efficacy of escitalopram in reducing PSD risk was more pronounced in the Baseline-Pink than in the Baseline-Blue group (p for interaction=0.058). Several risk factors differentially affected PSD development based on the presence of baseline depression (p for interaction <0.10). Cognitive dysfunction was an independent predictor of PSD in the Baseline-Blue, but not in the Baseline-Pink group, whereas the non-use of escitalopram and being female were more strongly associated with PSD in the Baseline-Pink group. CONCLUSIONS: Responses to escitalopram and predictors of PSD 3 months following stroke differed based on the presence of baseline depression. Our data suggest that PSD pathophysiology is heterogeneous; therefore, different therapeutic strategies may be needed to prevent PSD emergence following stroke. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Stroke Society | - |
dc.relation.isPartOf | JOURNAL OF STROKE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Differences in Therapeutic Responses and Factors Affecting Post-Stroke Depression at a Later Stage According to Baseline Depression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Eun-Jae Lee | - |
dc.contributor.googleauthor | Jong S Kim | - |
dc.contributor.googleauthor | Dae-Il Chang | - |
dc.contributor.googleauthor | Jong-Ho Park | - |
dc.contributor.googleauthor | Seong Hwan Ahn | - |
dc.contributor.googleauthor | Jae-Kwan Cha | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Sung-Il Sohn | - |
dc.contributor.googleauthor | Byung-Chul Lee | - |
dc.contributor.googleauthor | Dong-Eog Kim | - |
dc.contributor.googleauthor | Hahn Young Kim | - |
dc.contributor.googleauthor | Seongheon Kim | - |
dc.contributor.googleauthor | Do-Young Kwon | - |
dc.contributor.googleauthor | Jei Kim | - |
dc.contributor.googleauthor | Woo-Keun Seo | - |
dc.contributor.googleauthor | Jun Lee | - |
dc.contributor.googleauthor | Sang-Won Park | - |
dc.contributor.googleauthor | Seong-Ho Koh | - |
dc.contributor.googleauthor | Jin Young Kim | - |
dc.contributor.googleauthor | Smi Choi-Kwon | - |
dc.contributor.googleauthor | Min-Sun Kim | - |
dc.contributor.googleauthor | Ji Sung Lee | - |
dc.identifier.doi | 10.5853/jos.2017.02712 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J01758 | - |
dc.identifier.eissn | 2287-6405 | - |
dc.identifier.pmid | 29886724 | - |
dc.subject.keyword | Anger | - |
dc.subject.keyword | Depression | - |
dc.subject.keyword | Emotional incontinence | - |
dc.subject.keyword | Escitalopram | - |
dc.subject.keyword | Stroke | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.citation.volume | 20 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 258 | - |
dc.citation.endPage | 267 | - |
dc.identifier.bibliographicCitation | JOURNAL OF STROKE, Vol.20(2) : 258-267, 2018 | - |
dc.identifier.rimsid | 60082 | - |
dc.type.rims | ART | - |
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