Cited 24 times in
Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor
DC Field | Value | Language |
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dc.contributor.author | 김태수 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.contributor.author | 권우선 | - |
dc.date.accessioned | 2018-08-28T17:20:29Z | - |
dc.date.available | 2018-08-28T17:20:29Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162494 | - |
dc.description.abstract | Receptor tyrosine kinase MET (c-MET) has received considerable attention as a potential target for gastric cancer (GC) therapy and a number of c-MET inhibitors have been developed. For successful drug development, proper preclinical studies especially using patient derived cancer cell lines are very important. We profiled MET and MET-related characteristics in 49 GC cell lines to utilize them as models in preclinical studies of GC. Forty-nine cell lines were analyzed for genetic, biological, and molecular status to characterize MET and MET-related molecules. Four c-MET inhibitors were tested to elucidate the dependency on MET pathway in the 49 GC cell lines. Six of 49 cell lines were MET amplified with overexpression of c-MET and p-MET. The variants of MET were not associated with c-MET expression or amplification. Hs746T showed an exon 14 deletion in conjunction with MET amplification. The cell lines were divided into 6 MET amplified, 2 c-MET overexpressed, 2 hepatocyte growth factor (HGF) overexpressed, and 39 MET-negative subgroups. Except tivantinib, the c-MET inhibitors showed higher inhibition (%) in MET amplified than in MET nonamplified cell lines that MET amplified cell lines showed MET pathway dependency. However, the c-MET overexpressed and HGF overexpressed cell lines showed moderate dependency on MET pathway. Well-characterized cell lines are very important in studying drug development. Our 49 GC cell lines had various characteristics of MET and MET-related molecules and MET pathway dependency. These provide a promising platform for development of various RTK inhibitors including c-MET inhibitors. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor | - |
dc.type | Article | - |
dc.contributor.college | Others | - |
dc.contributor.department | Severance Hospital | - |
dc.contributor.googleauthor | Hyun Jeong Kim | - |
dc.contributor.googleauthor | Sun Kyoung Kang | - |
dc.contributor.googleauthor | Woo Sun Kwon | - |
dc.contributor.googleauthor | Tae Soo Kim | - |
dc.contributor.googleauthor | Inhye Jeong | - |
dc.contributor.googleauthor | Hei-Cheul Jeung | - |
dc.contributor.googleauthor | Michael Kragh | - |
dc.contributor.googleauthor | Ivan D Horak | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.identifier.doi | 10.1002/ijc.31304 | - |
dc.contributor.localId | A04549 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A03794 | - |
dc.relation.journalcode | J01092 | - |
dc.identifier.eissn | 1097-0215 | - |
dc.identifier.pmid | 29435981 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31304 | - |
dc.subject.keyword | HGF | - |
dc.subject.keyword | MET | - |
dc.subject.keyword | cell line | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | targeted therapy | - |
dc.contributor.alternativeName | Kim, Tae Soo | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Kim, Tae Soo | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.citation.volume | 143 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 151 | - |
dc.citation.endPage | 159 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, Vol.143(1) : 151-159, 2018 | - |
dc.identifier.rimsid | 60075 | - |
dc.type.rims | ART | - |
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