Cited 33 times in
Tumor-associated macrophages and crown-like structures in adipose tissue in breast cancer
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2018-08-28T17:19:34Z | - |
dc.date.available | 2018-08-28T17:19:34Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162482 | - |
dc.description.abstract | PURPOSE: We aimed to evaluate macrophage infiltration and to identify the status of crown-like structures (CLSs) in mammary adipose tissue of human breast tissue in cases with and without breast cancer. METHODS: Breast adipose tissue was obtained from reduction mammoplasty (N = 56, Group 1), non-neoplastic breast tissue of breast cancer patients (N = 84, Group 2), and breast cancer with adipose stroma (N = 140, Group 3). Immunohistochemical staining of CD68 and CD163 was performed, and the infiltrating macrophages and CLSs within breast adipose tissue were evaluated. RESULTS: Group 3 had the largest number of CD68-positive (CD68(+)) and CD163-positive (CD163(+)) macrophages and CLSs within adipose tissue (P < 0.001). Among Group 3, cases with high levels of CD68(+) and CD163(+) macrophages commonly had a higher histologic grade (P = 0.016 and P = 0.045), and cases with CD163(+) CLSs were correlated with old age (P = 0.042), estrogen receptor negativity (P = 0.013), human epidermal growth factor receptor-2 positivity (P = 0.043), and non-luminal A type (P = 0.039). Upon univariate analysis, high levels of CD163(+) macrophages were associated with shorter disease-free survival in node-negative breast cancer patients (P = 0.033), and CD68(+) CLSs were associated with shorter overall survival in node-positive breast cancer patients (P = 0.015). CONCLUSIONS: CD68(+) and/or CD163(+) tumor-associated macrophage infiltration as well as CLSs are present in adipose tissue nearby the breast cancer lesion, and are associated with various clinicopathologic parameters of breast cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Kluwer Academic | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Tumor-associated macrophages and crown-like structures in adipose tissue in breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Eun-Sol Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1007/s10549-018-4722-1 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J00403 | - |
dc.identifier.eissn | 1573-7217 | - |
dc.identifier.pmid | 29468486 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10549-018-4722-1 | - |
dc.subject.keyword | Adipocyte | - |
dc.subject.keyword | Breast | - |
dc.subject.keyword | Cancer | - |
dc.subject.keyword | Crown-like structure | - |
dc.subject.keyword | Macrophage | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 170 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 15 | - |
dc.citation.endPage | 25 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, Vol.170(1) : 15-25, 2018 | - |
dc.identifier.rimsid | 60063 | - |
dc.type.rims | ART | - |
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