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Prognostic factors for resected non-small cell lung cancer in patients with type 2 diabetes mellitus

DC FieldValueLanguage
dc.contributor.author김대준-
dc.contributor.author남경식-
dc.contributor.author박성용-
dc.contributor.author서지원-
dc.contributor.author유우식-
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.contributor.author정경영-
dc.date.accessioned2018-08-28T17:18:32Z-
dc.date.available2018-08-28T17:18:32Z-
dc.date.issued2018-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162466-
dc.description.abstractBACKGROUND: For diabetic patients with lung cancer, blood glucose levels and medications such as metformin and statins may influence survival. OBJECTIVES: This study aimed to determine prognostic survival factors for diabetic patients with resected non-small cell lung cancer. PATIENTS AND METHODS: Between January 2005 and December 2013, 301 patients with type 2 diabetes mellitus who underwent curative resection for non-small cell lung cancer were identified and reviewed retrospectively. RESULTS: The median follow-up period was 48 months. In multivariate analysis for lung cancer-specific survival, older age, forced expiratory volume in 1 s (FEV1) <80% predicted, and advanced pathologic stage were significant negative prognostic factors; statin use was a positive prognostic factor (hazard ratio (HR), 0.468). In multivariate analysis for overall survival, male sex, older age, comorbidity index, and advanced pathologic stage were significant negative prognostic factors and proper glycemic control (HR, 0.621) and statin use (HR, 0.585) were positive prognostic factors. CONCLUSIONS: Proper glycemic control (glycated hemoglobin A1c <7%) is recommended for diabetic patients undergoing lung cancer operations. Further studies are required to elucidate associations between type 2 diabetes mellitus and antineoplastic effects of statins and to evaluate statins as a novel adjuvant treatment for lung cancer.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJournal of Surgical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/etiology/*pathology/surgery-
dc.subject.MESHAged-
dc.subject.MESHNon-Small-Cell Lung/etiology/*pathology/surgery Carcinoma-
dc.subject.MESHSquamous Cell/etiology/*pathology/surgery Carcinoma-
dc.subject.MESHType 2/*complications Diabetes Mellitus-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/etiology/*pathology/surgery-
dc.subject.MESHMale-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.titlePrognostic factors for resected non-small cell lung cancer in patients with type 2 diabetes mellitus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery-
dc.contributor.googleauthorWoo Sik Yu-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorJee Won Suh-
dc.contributor.googleauthorKyoung Shik Narm-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorKyung Young Chung-
dc.contributor.googleauthorJin Gu Lee-
dc.identifier.doi10.1002/jso.24989-
dc.contributor.localIdA00368-
dc.contributor.localIdA04924-
dc.contributor.localIdA01508-
dc.contributor.localIdA04956-
dc.contributor.localIdA02486-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.contributor.localIdA03571-
dc.relation.journalcodeJ01762-
dc.identifier.eissn1096-9098-
dc.identifier.pmid29409112-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jso.24989-
dc.subject.keywordcarcinoma-
dc.subject.keywordtype 2 diabetes mellitus-
dc.subject.keywordhydroxymethylglutaryl-CoA reductase inhibitors-
dc.subject.keywordnon-small cell lung-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNameNarm, Kyoung Shik-
dc.contributor.alternativeNamePark, Seong Yong-
dc.contributor.alternativeNameShu, Jee Won-
dc.contributor.alternativeNameYu, Woo Sik-
dc.contributor.alternativeNameLee, Jin Gu-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorNarm, Kyoung Shik-
dc.contributor.affiliatedAuthorPark, Seong Yong-
dc.contributor.affiliatedAuthorShu, Jee Won-
dc.contributor.affiliatedAuthorYu, Woo Sik-
dc.contributor.affiliatedAuthorLee, Jin Gu-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.contributor.affiliatedAuthorChung, Kyung Young-
dc.citation.volume117-
dc.citation.number5-
dc.citation.startPage985-
dc.citation.endPage993-
dc.identifier.bibliographicCitationJournal of Surgical Oncology, Vol.117(5) : 985-993, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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