Cited 10 times in
Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis
DC Field | Value | Language |
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dc.contributor.author | 기현정 | - |
dc.contributor.author | 김미정 | - |
dc.contributor.author | 김현기 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 박수연 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 최윤영 | - |
dc.contributor.author | 최혜지 | - |
dc.date.accessioned | 2018-08-28T17:17:30Z | - |
dc.date.available | 2018-08-28T17:17:30Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162453 | - |
dc.description.abstract | Wntless/GPR177 functions as WNT ligand carrier protein and activator of WNT/beta-catenin signaling, however, its molecular role in gastric cancer (GC) has remained elusive. We investigated the role of GPR177 in gastric tumorigenesis and provided the therapeutic potential of a clinical development of anti-GPR177 monoclonal antibodies. GPR177 mRNA expression was assessed in GC transcriptome data sets (GSE15459, n = 184; GSE66229, n = 300); protein expression was assessed in independent patient tumor tissues (Yonsei TMA, n = 909). GPR177 expression were associated with unfavorable prognosis [log-rank test, GSE15459 (P = 0.00736), GSE66229 (P = 0.0142), and Yonsei TMA (P = 0.0334)] and identified as an independent risk predictor of clinical outcomes: GSE15459 [hazard ratio (HR) 1.731 (95% confidence interval; CI; 1.103- 2.715), P = 0.017], GSE66229 [HR 1.54 (95% CI, 1.10-2.151), P = 0.011], and Yonsei TMA [HR 1.254 (95% CI, 1.049- 1.500), P = 0.013]. Either antibody treatment or GPR177 knockdown suppressed proliferation of GC cells and sensitized cells to apoptosis. And also inhibition of GPR177 suppresses in vitro and in vivo tumorogenesis in GC cells and inhibits WNT/beta-catenin signaling. Finally, targeting and inhibition of GPR177 with antibody suppressed tumorigenesis in PDX model. Together, these results suggest GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of GC patients. [BMB Reports 2018; 51(5): 255-260]. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Biochemistry and Molecular Biology | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis | - |
dc.type | Article | - |
dc.contributor.college | Research Institutes | - |
dc.contributor.department | Research Institute of Radiological Science | - |
dc.contributor.googleauthor | Jaesung Seo | - |
dc.contributor.googleauthor | Hyun Jung Kee | - |
dc.contributor.googleauthor | Hye Ji Choi | - |
dc.contributor.googleauthor | Jae Eun Lee | - |
dc.contributor.googleauthor | Soo-Yeon Park | - |
dc.contributor.googleauthor | Seung-Hyun Lee | - |
dc.contributor.googleauthor | Mi-Hyeon Jeong | - |
dc.contributor.googleauthor | Garam Guk | - |
dc.contributor.googleauthor | SooYeon Lee | - |
dc.contributor.googleauthor | Kyung-Chul Choi | - |
dc.contributor.googleauthor | Yoon Young Choi | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.identifier.doi | 10.5483/BMBRep.2018.51.5.046 | - |
dc.contributor.localId | A00279 | - |
dc.contributor.localId | A00450 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01534 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A02932 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A04138 | - |
dc.contributor.localId | A05525 | - |
dc.relation.journalcode | J00348 | - |
dc.identifier.eissn | 1976-670X | - |
dc.identifier.pmid | 29555015 | - |
dc.contributor.alternativeName | Kee, Hyun Jung | - |
dc.contributor.alternativeName | Kim, Mi Jeong | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Park, Soo Yeon | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Lee, Seung Hyun | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Choi, Yoon Young | - |
dc.contributor.alternativeName | Choi, Hye Ji | - |
dc.contributor.affiliatedAuthor | Kee, Hyun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Mi Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Park, Soo Yeon | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Choi, Yoon Young | - |
dc.contributor.affiliatedAuthor | Choi, Hye Ji | - |
dc.citation.volume | 51 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 255 | - |
dc.citation.endPage | 260 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, Vol.51(5) : 255-260, 2018 | - |
dc.identifier.rimsid | 60035 | - |
dc.type.rims | ART | - |
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