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Cardiovascular involvement in systemic rheumatic diseases: An integrated view for the treating physicians

Authors
 Kwang Seob Lee  ;  Andreas Kronbichler  ;  Michael Eisenhut  ;  Keum Hwa Lee  ;  Jae Il Shin 
Citation
 Autoimmunity Reviews, Vol.17(3) : 201-214, 2018 
Journal Title
 Autoimmunity Reviews 
ISSN
 1568-9972 
Issue Date
2018
MeSH
Cardiovascular Diseases/*etiology/pathology ; Humans ; Physicians/*standards ; Rheumatic Diseases/*complications/pathology ; Risk Factors
Keywords
Cardiovascular involvement ; Disease-modifying anti-rheumatic drug ; Systemic rheumatic disease ; Toxicity
Abstract
Systemic autoimmune diseases can affect various kinds of organs including the kidney, the skin, soft tissue and the bone. Among others, cardiovascular involvement in rheumatic diseases has been shown to affect myocardium, pericardium, cardiac vessels, conduction system and valves, eventually leading to increased mortality. In general, underlying chronic inflammation leads to premature atherosclerosis, but also other manifestations such as arrhythmia and heart failure may have a 'silent' progress. Traditional cardiovascular risk factors play a secondary role, while disease-specific factors (i.e. disease duration, severity, antibody positivity, persistent disease activity) can directly influence the cardiovascular system. Therefore, early diagnosis is critical to optimize management and to control inflammatory activity and recent data suggest that risk factors (i.e. hypercholesterolemia and hypertension) need intensive treatment as well. With the advent of immunosuppressive agents, most rheumatic diseases are well controlled on treatment, but information related to their cardioprotective efficacy is not well-defined. In this review, we focus on cardiovascular involvement in rheumatic diseases and highlight current evidence which should be of help for the treating physicians. Moreover, cardiotoxicity of immunosuppressive drugs is a rare issue and such potential adverse events will be briefly discussed.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162448
Full Text
https://www.sciencedirect.com/science/article/pii/S1568997218300041
DOI
10.1016/j.autrev.2017.12.001
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
신재일(Shin, Jae Il) ORCID logo https://orcid.org/0000-0003-2326-1820
이금화(Lee, Keum Hwa)
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