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Design of Magnetically Labeled Cells (Mag-Cells) for in Vivo Control of Stem Cell Migration and Differentiation

DC FieldValueLanguage
dc.contributor.author박국인-
dc.contributor.author김일선-
dc.date.accessioned2018-08-28T17:16:49Z-
dc.date.available2018-08-28T17:16:49Z-
dc.date.issued2018-
dc.identifier.issn1530-6984-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162441-
dc.description.abstractCell-based therapies are attractive for treating various degenerative disorders and cancer but delivering functional cells to the region of interest in vivo remains difficult. The problem is exacerbated in dense biological matrices such as solid tissues because these environments impose significant steric hindrances for cell movement. Here, we show that neural stem cells transfected with zinc-doped ferrite magnetic nanoparticles (ZnMNPs) can be pulled by an external magnet to migrate to the desired location in the brain. These magnetically labeled cells (Mag-Cells) can migrate because ZnMNPs generate sufficiently strong mechanical forces to overcome steric hindrances in the brain tissues. Once at the site of lesion, Mag-Cells show enhanced neuronal differentiation and greater secretion of neurotrophic factors than unlabeled control stem cells. Our study shows that ZnMNPs activate zinc-mediated Wnt signaling to facilitate neuronal differentiation. When implemented in a rodent brain stroke model, Mag-Cells led to significant recovery of locomotor performance in the impaired limbs of the animals. Our findings provide a simple magnetic method for controlling migration of stem cells with high therapeutic functions, offering a valuable tool for other cell-based therapies.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfNano Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDesign of Magnetically Labeled Cells (Mag-Cells) for in Vivo Control of Stem Cell Migration and Differentiation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorSeokhwan Yun-
dc.contributor.googleauthorTae-Hyun Shin-
dc.contributor.googleauthorJae-Hyun Lee-
dc.contributor.googleauthorMi Hyeon Cho-
dc.contributor.googleauthorIl-Sun Kim-
dc.contributor.googleauthorJi-Wook Kim-
dc.contributor.googleauthorKwangsoo Jung-
dc.contributor.googleauthorIl-Shin Lee-
dc.contributor.googleauthorJinwoo Cheon-
dc.contributor.googleauthorKook In Park-
dc.identifier.doi10.1021/acs.nanolett.7b04089-
dc.contributor.localIdA01438-
dc.relation.journalcodeJ02283-
dc.identifier.eissn1530-6992-
dc.identifier.pmid29393650-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acs.nanolett.7b04089-
dc.subject.keywordMagnetic nanoparticles-
dc.subject.keywordcell therapy-
dc.subject.keywordmagnetic targeting-
dc.subject.keywordstem cell delivery-
dc.subject.keywordstem cell differentiation-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.citation.volume18-
dc.citation.number2-
dc.citation.startPage838-
dc.citation.endPage845-
dc.identifier.bibliographicCitationNano Letters, Vol.18(2) : 838-845, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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