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Design of Magnetically Labeled Cells (Mag-Cells) for in Vivo Control of Stem Cell Migration and Differentiation

Authors
 Seokhwan Yun  ;  Tae-Hyun Shin  ;  Jae-Hyun Lee  ;  Mi Hyeon Cho  ;  Il-Sun Kim  ;  Ji-Wook Kim  ;  Kwangsoo Jung  ;  Il-Shin Lee  ;  Jinwoo Cheon  ;  Kook In Park 
Citation
 Nano Letters, Vol.18(2) : 838-845, 2018 
Journal Title
 Nano Letters 
ISSN
 1530-6984 
Issue Date
2018
Keywords
Magnetic nanoparticles ; cell therapy ; magnetic targeting ; stem cell delivery ; stem cell differentiation
Abstract
Cell-based therapies are attractive for treating various degenerative disorders and cancer but delivering functional cells to the region of interest in vivo remains difficult. The problem is exacerbated in dense biological matrices such as solid tissues because these environments impose significant steric hindrances for cell movement. Here, we show that neural stem cells transfected with zinc-doped ferrite magnetic nanoparticles (ZnMNPs) can be pulled by an external magnet to migrate to the desired location in the brain. These magnetically labeled cells (Mag-Cells) can migrate because ZnMNPs generate sufficiently strong mechanical forces to overcome steric hindrances in the brain tissues. Once at the site of lesion, Mag-Cells show enhanced neuronal differentiation and greater secretion of neurotrophic factors than unlabeled control stem cells. Our study shows that ZnMNPs activate zinc-mediated Wnt signaling to facilitate neuronal differentiation. When implemented in a rodent brain stroke model, Mag-Cells led to significant recovery of locomotor performance in the impaired limbs of the animals. Our findings provide a simple magnetic method for controlling migration of stem cells with high therapeutic functions, offering a valuable tool for other cell-based therapies.
Full Text
https://pubs.acs.org/doi/10.1021/acs.nanolett.7b04089
DOI
10.1021/acs.nanolett.7b04089
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Il-Sun(김일선) ORCID logo https://orcid.org/0000-0003-4033-4323
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162441
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