Cited 22 times in
Plasma Cell-Free DNA as a Predictive Marker after Radiotherapy for Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | 성진실 | - |
dc.date.accessioned | 2018-08-28T17:15:00Z | - |
dc.date.available | 2018-08-28T17:15:00Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162405 | - |
dc.description.abstract | PURPOSE: Cell-free DNA (cfDNA) is gaining attention as a novel biomarker for oncologic outcomes. We investigated the clinical significance of cfDNA in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT). MATERIALS AND METHODS: Fifty-five patients with HCC who received RT were recruited from two prospective study cohorts: one cohort of 34 patients who underwent conventionally fractionated RT and a second of 21 patients treated with stereotactic body radiation therapy. cfDNA was extracted and quantified. RESULTS: In total, 30% of the patients had multiple tumors, 77% had tumors >2 cm, and 32% had portal vein tumor thrombus. Optimal cut-off values for cfDNA levels (33.65 ng/mL and 37.25 ng/mL, before and after RT) were used to divide patients into low-DNA (LDNA) and high-DNA (HDNA) groups. The pre-RT HDNA group tended to have more advanced disease and larger tumors (p=0.049 and p=0.017, respectively). Tumor response, intrahepatic failure-free rates, and local control (LC) rates were significantly better in the post-RT LDNA group (p=0.017, p=0.035, and p=0.006, respectively). CONCLUSION: Quantitative analysis of cfDNA was feasible in our cohorts. Post-RT cfDNA levels were negatively correlated with treatment outcomes, indicating the potential for the use of post-RT cfDNA levels as an early predictor of treatment responses and LC after RT for HCC patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Tumor/*blood Biomarkers | - |
dc.subject.MESH | Hepatocellular/blood/genetics/pathology/*radiotherapy Carcinoma | - |
dc.subject.MESH | Cell-Free Nucleic Acids/*blood/*genetics | - |
dc.subject.MESH | Circulating Tumor DNA/*blood | - |
dc.subject.MESH | DNA | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/blood/genetics/pathology/*radiotherapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Portal Vein | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Plasma Cell-Free DNA as a Predictive Marker after Radiotherapy for Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Sangjoon Park | - |
dc.contributor.googleauthor | Eun Jung Lee | - |
dc.contributor.googleauthor | Chai Hong Rim | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.identifier.doi | 10.3349/ymj.2018.59.4.470 | - |
dc.contributor.localId | A01956 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 29749129 | - |
dc.subject.keyword | Biomarkers | - |
dc.subject.keyword | cell-free DNA | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | radiotherapy | - |
dc.subject.keyword | treatment | - |
dc.subject.keyword | tumor | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.citation.volume | 59 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 470 | - |
dc.citation.endPage | 479 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.59(4) : 470-479, 2018 | - |
dc.identifier.rimsid | 59989 | - |
dc.type.rims | ART | - |
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