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Effect of Non-vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation Patients with Newly Diagnosed Cancer

 Kyu Kim  ;  Yong Joon Lee  ;  Tae Hoon Kim  ;  Jae Sun Uhm  ;  Hui Nam Pak  ;  Moon Hyoung Lee  ;  Boyoung Joung 
 Korean Circulation Journal, Vol.48(5) : 406-417, 2018 
Journal Title
 Korean Circulation Journal 
Issue Date
Anticoagulants ; Atrial fibrillation ; Hemorrhage ; Neoplasms ; Stroke
BACKGROUND AND OBJECTIVES: There are limited data on the use of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with cancer. We aimed to assess the efficacy and safety of NOACs in AF patients with cancer in this study. METHODS: In 2,568 consecutive non-valvular AF patients with newly diagnosed cancer, we analyzed ischemic stroke/systemic embolism (SE), major bleeding, and all-cause death. Based on propensity score matching, 388 matched pairs were included in the NOAC and warfarin groups. RESULTS: Patient baseline characteristics were comparable between the matched groups. During median follow-up of 1.8 years, the NOAC group had significantly lower incidences of ischemic stroke/SE (p<0.001), major bleeding (p<0.001), and all-cause death (p<0.001) than the warfarin group. Moreover, the incidence of major bleeding was significantly lower in the NOAC group than in the warfarin group with optimal international normalized ratio control (p=0.03). Especially, within 1 year after cancer diagnosis, the incidences of all clinical events were significantly lower in the NOAC group than in the warfarin group. CONCLUSIONS: In AF patients with newly diagnosed cancer, NOACs showed lower incidences of ischemic stroke/SE, major bleeding, and all-cause death than warfarin, especially within 1 year after cancer diagnosis.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실)
Yonsei Authors
김규(Kim, Kyu)
김태훈(Kim, Tae-Hoon) ORCID logo https://orcid.org/0000-0003-4200-3456
박희남(Pak, Hui Nam) ORCID logo https://orcid.org/0000-0002-3256-3620
엄재선(Uhm, Jae Sun) ORCID logo https://orcid.org/0000-0002-1611-8172
이문형(Lee, Moon Hyoung) ORCID logo https://orcid.org/0000-0002-7268-0741
이용준(Lee, Yong Joon)
정보영(Joung, Bo Young) ORCID logo https://orcid.org/0000-0001-9036-7225
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