48 89

Cited 0 times in

Partial Conduction Block as an Early Nerve Conduction Finding in Neurolymphomatosis

DC FieldValueLanguage
dc.contributor.author김세훈-
dc.contributor.author김승민-
dc.contributor.author신하영-
dc.contributor.author정하늘-
dc.contributor.author최영철-
dc.date.accessioned2018-08-28T17:09:32Z-
dc.date.available2018-08-28T17:09:32Z-
dc.date.issued2018-
dc.identifier.issn1738-6586-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162319-
dc.description.abstractBACKGROUND AND PURPOSE: Neurolymphomatosis is a rare manifestation of hematological malignancy and is characterized by direct infiltration of the peripheral nervous system. The objective of this study was to identify the clinical and electrophysiological features of neurolymphomatosis. METHODS: We retrospectively analyzed the medical records of 13 patients with neurolymphomatosis. Seven (54%) of the patients were men, and the median age at symptom onset was 60.0 years. RESULTS: The most common type of underlying malignancy was diffuse large B-cell lymphoma (69%). Twelve patients had painful asymmetric neuropathies. The median survival time after diagnosis was 7 months, and 12 patients died during the study period. Thirty-eight motor nerve conduction studies (NCSs) were performed in the affected nerves. Ten and 28 motor nerves were classified into the conduction-block and simple-axon-degeneration groups, respectively. The median time interval between symptom onset and the NCS was significantly shorter in the conduction-block group than in the simple-axon-degeneration group (p=0.032). However, no significant differences in the motor nerve conduction velocities, terminal latencies, and distal compound muscle action potential amplitudes were identified between the conduction-block and simple-axon-degeneration groups. The conduction-block group showed excessive temporal dispersion in only five of the ten NCSs (50%). Follow-up NCSs revealed that partial conduction blocks had changed into axonal degeneration patterns. CONCLUSIONS: This is the first study to analyze the electrophysiological features of patients with neurolymphomatosis. Our findings showed that a partial conduction block is not rare and is an early nerve conduction abnormality in neurolymphomatosis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Neurological Association-
dc.relation.isPartOfJournal of Clinical Neurology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePartial Conduction Block as an Early Nerve Conduction Finding in Neurolymphomatosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorHyung Jun Park-
dc.contributor.googleauthorHa Young Shin-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorHa Neul Jeong-
dc.contributor.googleauthorYoung Chul Choi-
dc.contributor.googleauthorBum Chun Suh-
dc.contributor.googleauthorKee Duk Park-
dc.contributor.googleauthorSeung Min Kim-
dc.identifier.doi10.3988/jcn.2018.14.1.73-
dc.contributor.localIdA00610-
dc.contributor.localIdA00653-
dc.contributor.localIdA02170-
dc.contributor.localIdA05515-
dc.contributor.localIdA04116-
dc.relation.journalcodeJ01327-
dc.identifier.eissn2005-5013-
dc.identifier.pmid29629543-
dc.subject.keywordconduction block-
dc.subject.keywordleukemia-
dc.subject.keywordlymphoma-
dc.subject.keywordnerve conduction study-
dc.subject.keywordneurolymphomatosis-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Seung Min-
dc.contributor.alternativeNameShin, Ha Young-
dc.contributor.alternativeNameJeong, Ha Neul-
dc.contributor.alternativeNameChoi, Young Chul-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorKim, Seung Min-
dc.contributor.affiliatedAuthorShin, Ha Young-
dc.contributor.affiliatedAuthorJeong, Ha Neul-
dc.contributor.affiliatedAuthorChoi, Young Chul-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage73-
dc.citation.endPage80-
dc.identifier.bibliographicCitationJournal of Clinical Neurology, Vol.14(1) : 73-80, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.