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Clinicopathological Characteristics and KRAS Mutation Status of Endometrial Mucinous Metaplasia and Carcinoma

DC FieldValueLanguage
dc.contributor.author김현수-
dc.date.accessioned2018-08-28T17:08:39Z-
dc.date.available2018-08-28T17:08:39Z-
dc.date.issued2018-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162301-
dc.description.abstractBACKGROUND/AIM: Mucinous metaplasia of the endometrium occurs as a spectrum of epithelial alterations ranging from the formation of simple, tubular glands to architecturally complex glandular proliferation with intraglandular papillary projection and cellular tufts. Endometrial mucinous metaplasia often presents a diagnostic challenge in endometrial curettage. MATERIALS AND METHODS: We analyzed the clinicopathological characteristics and the mutation status for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) of 11 cases of endometrial mucinous metaplasia. Electronic medical record review and histopathological examination were performed. KRAS mutation status was analyzed using a pyrosequencing technique. RESULTS: Cases were classified histopathologically into simple (5/11) or papillary (6/11) mucinous metaplasias. All (6/6) papillary mucinous metaplasias were associated with atypical hyperplasia/endometrioid intraepithelial neoplasia (AH/EIN; 1/6) or carcinoma (5/6), whereas in a single patient with simple mucinous metaplasia, grade 1 endometrioid carcinoma was incidentally detected. The difference in frequency of association of the metaplasia with AH/EIN or carcinoma was significant (p=0.015). KRAS mutations were identified in five out of six cases of papillary mucinous metaplasias, comprising three cases with G12D and two with G12V mutations; the frequency of KRAS mutation was significantly higher (p=0.015) than in cases of simple mucinous metaplasia (0/5). CONCLUSION: Papillary mucinous metaplasia is frequently associated with endometrial neoplastic lesions. The high incidence of KRAS mutations in papillary mucinous metaplasia suggests that papillary mucinous metaplasia may be a precancerous lesion of a certain subset of mucinous carcinomas of the endometrium.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.isPartOfANTICANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHMucinous/*genetics/pathology Adenocarcinoma-
dc.subject.MESHPapillary/genetics/pathology Adenocarcinoma-
dc.subject.MESHAdult-
dc.subject.MESHEndometrioid/genetics/pathology Carcinoma-
dc.subject.MESHEndometrial Neoplasms/*genetics/*pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMetaplasia/genetics/pathology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrecancerous Conditions/genetics/pathology-
dc.subject.MESHProto-Oncogene Proteins p21(ras)/*genetics-
dc.titleClinicopathological Characteristics and KRAS Mutation Status of Endometrial Mucinous Metaplasia and Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorJi-Youn Sung-
dc.contributor.googleauthorYoon Yang Jung-
dc.contributor.googleauthorHyun-Soo Kim-
dc.identifier.doi10.21873/anticanres.12521-
dc.contributor.localIdA01114-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid29715099-
dc.identifier.urlhttp://ar.iiarjournals.org/content/38/5/2779.abstract-
dc.subject.keywordEndometrium-
dc.subject.keywordKRAS-
dc.subject.keywordcarcinoma-
dc.subject.keywordmetaplasia-
dc.subject.keywordmucinous-
dc.subject.keywordpapillary-
dc.contributor.alternativeNameKim, Hyun-Soo-
dc.contributor.affiliatedAuthorKim, Hyun-Soo-
dc.citation.volume38-
dc.citation.number5-
dc.citation.startPage2779-
dc.citation.endPage2786-
dc.identifier.bibliographicCitationANTICANCER RESEARCH, Vol.38(5) : 2779-2786, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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