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The roles of (11)C-acetate PET/CT in predicting tumor differentiation and survival in patients with cerebral glioma

Authors
 Soyoung Kim  ;  Dongwoo Kim  ;  Se Hoon Kim  ;  Mi-Ae Park  ;  Jong Hee Chang  ;  Mijin Yun 
Citation
 European Journal of Nuclear Medicine and Molecular Imaging, Vol.45(6) : 1012-1020, 2018 
Journal Title
 European Journal of Nuclear Medicine and Molecular Imaging 
ISSN
 1619-7070 
Issue Date
2018
Keywords
Acetate ; Glioma ; Grading ; Positron emission tomography ; Prognosis
Abstract
PURPOSE: This prospective study aimed to evaluate the clinical values of (11)C-acetate positron emission tomography/computed tomography (PET/CT) in predicting histologic grades and survival in patients with cerebral glioma. METHODS: Seventy-three patients with surgically confirmed cerebral gliomas (19 grade II, 21 grade III, and 33 grade IV) who underwent (11)C-acetate PET/CT before surgery were included. Tumor-to-choroid plexus ratio (TCR), which was defined as the maximum standardized uptake value (SUV) of tumors to the mean SUV of choroid plexus, was compared between three World Health Organization (WHO) grade groups. Moreover, metabolic tumor volumes (MTV) were calculated. Progression-free survival (PFS) and overall survival (OS) curves were plotted using the Kaplan-Meier method, and differences in survival between groups were assessed using the log-rank test. RESULTS: Median TCR was 1.20 (interquartile range [IQR], 1.14 to 1.4) in grade II, 1.65 (IQR, 1.26 to 1.79) in grade III, and 2.53 (IQR, 1.93 to 3.30) in grade IV gliomas. Significant differences in TCR were seen among the three WHO grade groups (P < 0.001). In Cox regression analysis including TCR, MTV, molecular markers, and other clinical factors, TCR was prognostic for PFS (P = 0.016) and TCR and MTV were prognostic for OS (P = 0.024 [TCR], P = 0.030 [MTV]). PFS and OS were significantly shorter in patients with a TCR >/= 1.6 than in those with a TCR < 1.6. OS were significantly shorter in patients with a MTV >/= 1 than in those with a TCR < 1. CONCLUSIONS: TCR on (11)C-acetate PET/CT significantly differed between low- and high-grade cerebral gliomas, and it showed the capability to further differentiate grade III from grade IV tumors. TCR and MTV were independent prognostic factors and predicted survival better than did the WHO grade.
Full Text
https://link.springer.com/article/10.1007%2Fs00259-018-3948-9
DOI
10.1007/s00259-018-3948-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dongwoo(김동우) ORCID logo https://orcid.org/0000-0002-1723-604X
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Soyoung(김소영) ORCID logo https://orcid.org/0000-0002-6163-1434
Park, Mi-Ae(박미애)
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Chang, Jong Hee(장종희)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162291
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