Cited 6 times in
Intranuclear delivery of the transcription modulation domain of Tbet-improved lupus nephritis in (NZB/NZW) F1 lupus-prone mice
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 이상원 | - |
dc.date.accessioned | 2018-08-28T17:07:21Z | - |
dc.date.available | 2018-08-28T17:07:21Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162277 | - |
dc.description.abstract | Excessive expression of Tbet and IFNgamma is evidence of systemic lupus erythematosus (SLE) in lupus patients. In this study, the nucleus-transducible form of Transcription Modulation Domain (TMD) of Tbet (ntTbet-TMD), which is a fusion protein between Protein Transduction Domain Hph-1 (Hph-1-PTD) and the TMD of Tbet comprising DNA binding domain and isotype-specific domain, was generated to inhibit Tbet-mediated transcription in the interactomic manner. ntTbet-TMD was effectively delivered into the nucleus of the cells and specifically inhibited Tbet-mediated transcription without influencing the differentiation of other T cell subsets and signaling events for T cell activation. The severity of nephritis was significantly reduced by ntTbet-TMD as effectively as methylprednisolone in lupus-prone mice. The number of Th1, Th2 or Th17 cells and the secretion of their cytokines substantially decreased in the spleen and kidney of lupus-prone mice by ntTbet-TMD treatment. In contrast to methylprednisolone, the marked increase of Treg cells and the secretion of their immunosuppressive cytokine were detected in the spleen of (NZB/NZW) F1 mice treated with ntTbet-TMD. Thus, ntTbet-TMD can improve nephritis in lupus-prone mice by modulating the overall proinflammatory microenvironment and rebalancing T cell subsets, leading to new immune therapeutics for Th1-mediated autoimmune diseases. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | KIDNEY INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Intranuclear delivery of the transcription modulation domain of Tbet-improved lupus nephritis in (NZB/NZW) F1 lupus-prone mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jae-Seung Moon | - |
dc.contributor.googleauthor | Chin Hee Mun | - |
dc.contributor.googleauthor | Jung-Ho Kim | - |
dc.contributor.googleauthor | Jen-Young Cho | - |
dc.contributor.googleauthor | Sung-Dong Park | - |
dc.contributor.googleauthor | Tae-Yoon Park | - |
dc.contributor.googleauthor | Jin-Su Shin | - |
dc.contributor.googleauthor | Chun-Chang Ho | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Sankar Ghosh | - |
dc.contributor.googleauthor | Alfred L M Bothwell | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Sang-Kyou Lee | - |
dc.identifier.doi | 10.1016/j.kint.2017.11.017 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J01941 | - |
dc.identifier.eissn | 1523-1755 | - |
dc.identifier.pmid | 29409726 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0085253817308530 | - |
dc.subject.keyword | T helper 1 cells | - |
dc.subject.keyword | Tbet | - |
dc.subject.keyword | Treg cells | - |
dc.subject.keyword | inflammatory microenvironment | - |
dc.subject.keyword | nucleus-transducible form | - |
dc.subject.keyword | systemic lupus erythematosus | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.citation.volume | 93 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1118 | - |
dc.citation.endPage | 1130 | - |
dc.identifier.bibliographicCitation | KIDNEY INTERNATIONAL, Vol.93(5) : 1118-1130, 2018 | - |
dc.identifier.rimsid | 59863 | - |
dc.type.rims | ART | - |
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