Cited 3 times in
Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study
DC Field | Value | Language |
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dc.contributor.author | 김태현 | - |
dc.contributor.author | 박은철 | - |
dc.date.accessioned | 2018-08-28T17:05:41Z | - |
dc.date.available | 2018-08-28T17:05:41Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1743-7555 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162245 | - |
dc.description.abstract | BACKGROUND: Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS: We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. RESULTS: The total number of person-years of follow-up was 397 780 and 60.2% of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR] = 1.32, CI 1.29-1.35; pneumonia, HR = 1.14, CI 1.08-1.19; and asthma, HR = 1.11, CI 1.06-1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR = 2.91, CI 2.82-3.00; pneumonia, HR = 1.67, CI 1.51-1.85; asthma, HR = 1.56, CI 1.45-1.68; and tuberculosis, HR = 2.03, CI 1.90-2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. CONCLUSION: Hazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Pub. Asia | - |
dc.relation.isPartOf | ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | 80 and over Aged | - |
dc.subject.MESH | Asthma/*complications/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/*etiology/mortality | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Chronic Obstructive/*complications/pathology Pulmonary Disease | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Young Adult | - |
dc.title | Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health | - |
dc.contributor.department | Graduate School of Public Health | - |
dc.contributor.googleauthor | Seri Hong | - |
dc.contributor.googleauthor | Eun-Cheol Park | - |
dc.contributor.googleauthor | Tae Hyun Kim | - |
dc.contributor.googleauthor | Jeoung A Kwon | - |
dc.contributor.googleauthor | Ki-Bong Yoo | - |
dc.contributor.googleauthor | Kyu-Tae Han | - |
dc.contributor.googleauthor | Ji Won Yoo | - |
dc.contributor.googleauthor | Sun Jung Kim | - |
dc.identifier.doi | 10.1111/ajco.12697 | - |
dc.contributor.localId | A01082 | - |
dc.contributor.localId | A01618 | - |
dc.relation.journalcode | J00257 | - |
dc.identifier.eissn | 1743-7563 | - |
dc.identifier.pmid | 28762660 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1111/ajco.12697 | - |
dc.subject.keyword | lung neoplasms | - |
dc.subject.keyword | pre-existing condition | - |
dc.subject.keyword | respiratory tract diseases | - |
dc.subject.keyword | survival | - |
dc.contributor.alternativeName | Kim, Tae Hyun | - |
dc.contributor.alternativeName | Park, Eun Chul | - |
dc.contributor.affiliatedAuthor | Kim, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Park, Eun Chul | - |
dc.citation.volume | 14 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e71 | - |
dc.citation.endPage | e80 | - |
dc.identifier.bibliographicCitation | ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Vol.14(2) : e71-e80, 2018 | - |
dc.identifier.rimsid | 59831 | - |
dc.type.rims | ART | - |
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