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Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study

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dc.contributor.author김태현-
dc.contributor.author박은철-
dc.date.accessioned2018-08-28T17:05:41Z-
dc.date.available2018-08-28T17:05:41Z-
dc.date.issued2018-
dc.identifier.issn1743-7555-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162245-
dc.description.abstractBACKGROUND: Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS: We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. RESULTS: The total number of person-years of follow-up was 397 780 and 60.2% of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR] = 1.32, CI 1.29-1.35; pneumonia, HR = 1.14, CI 1.08-1.19; and asthma, HR = 1.11, CI 1.06-1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR = 2.91, CI 2.82-3.00; pneumonia, HR = 1.67, CI 1.51-1.85; asthma, HR = 1.56, CI 1.45-1.68; and tuberculosis, HR = 2.03, CI 1.90-2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. CONCLUSION: Hazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Pub. Asia-
dc.relation.isPartOfASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESH80 and over Aged-
dc.subject.MESHAsthma/*complications/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/*etiology/mortality-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHChronic Obstructive/*complications/pathology Pulmonary Disease-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHYoung Adult-
dc.titleEffect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health-
dc.contributor.departmentGraduate School of Public Health-
dc.contributor.googleauthorSeri Hong-
dc.contributor.googleauthorEun-Cheol Park-
dc.contributor.googleauthorTae Hyun Kim-
dc.contributor.googleauthorJeoung A Kwon-
dc.contributor.googleauthorKi-Bong Yoo-
dc.contributor.googleauthorKyu-Tae Han-
dc.contributor.googleauthorJi Won Yoo-
dc.contributor.googleauthorSun Jung Kim-
dc.identifier.doi10.1111/ajco.12697-
dc.contributor.localIdA01082-
dc.contributor.localIdA01618-
dc.relation.journalcodeJ00257-
dc.identifier.eissn1743-7563-
dc.identifier.pmid28762660-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/ajco.12697-
dc.subject.keywordlung neoplasms-
dc.subject.keywordpre-existing condition-
dc.subject.keywordrespiratory tract diseases-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameKim, Tae Hyun-
dc.contributor.alternativeNamePark, Eun Chul-
dc.contributor.affiliatedAuthorKim, Tae Hyun-
dc.contributor.affiliatedAuthorPark, Eun Chul-
dc.citation.volume14-
dc.citation.number2-
dc.citation.startPagee71-
dc.citation.endPagee80-
dc.identifier.bibliographicCitationASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Vol.14(2) : e71-e80, 2018-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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