Cited 6 times in
Inhibition of insulin-like growth factor receptor-1 reduces necroptosis-related markers and attenuates LPS-induced lung injury in mice
DC Field | Value | Language |
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dc.contributor.author | 김영삼 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 송주한 | - |
dc.contributor.author | 임아영 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정경수 | - |
dc.date.accessioned | 2018-08-28T17:05:33Z | - |
dc.date.available | 2018-08-28T17:05:33Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162243 | - |
dc.description.abstract | Insulin-like growth factor-1 (IGF-1) levels are known to increase in the bronchoalveolar lavage fluid (BALF) of patients with acute respiratory distress syndrome. Herein, we investigated the role of IGF-1 in lipopolysaccharide (LPS)-induced lung injury. In LPS-treated cells, expressions of receptor-interacting protein 3 (RIP3) and phosphorylated mixed lineage kinase domain-like protein (MLKL) were decreased in IGF-1 receptor small interfering RNA (siRNA)-treated cells compared to control cells. The levels of pro-inflammatory cytokines including interleukin (IL)-1beta, IL-6, IL-10, tumour necrosis factor-alpha, and macrophage inflammatory protein 2/C-X-C motif chemokine ligand 2 in the supernatant were significantly reduced in IGF-1 receptor siRNA-treated cells compared to control cells. In LPS-induced murine lung injury model, total cell counts, polymorphonuclear leukocytes counts, and pro-inflammatory cytokine levels in the BALF were significantly lower and histologically detected lung injury was less common in the group treated with IGF-1 receptor monoclonal antibody compared to the non-treated group. On western blotting, RIP3 and phosphorylated MLKL expressions were relatively decreased in the IGF-1 receptor monoclonal antibody group compared to the non-treated group. IGF-1 may be associated with RIP3-mediated necroptosis in vitro, while blocking of the IGF-1 pathway may reduce LPS-induced lung injuries in vivo. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | CD/metabolism Antigens | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Bronchoalveolar Lavage Fluid/chemistry/cytology/immunology | - |
dc.subject.MESH | Cadherins/metabolism | - |
dc.subject.MESH | Lipopolysaccharides | - |
dc.subject.MESH | Lung/metabolism | - |
dc.subject.MESH | Lung Injury/chemically induced/*prevention & control | - |
dc.subject.MESH | Macrophages/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Necrosis/*etiology | - |
dc.subject.MESH | IGF Type 1/antagonists & inhibitors/*pharmacology/physiology Receptor | - |
dc.subject.MESH | Receptor-Interacting Protein Serine-Threonine Kinases/metabolism | - |
dc.title | Inhibition of insulin-like growth factor receptor-1 reduces necroptosis-related markers and attenuates LPS-induced lung injury in mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Su Hwan Lee | - |
dc.contributor.googleauthor | Ju Hye Shin | - |
dc.contributor.googleauthor | Joo Han Song | - |
dc.contributor.googleauthor | Ah Young Leem | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Kyung Soo Chung | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.03.074 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A02062 | - |
dc.contributor.localId | A03382 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03570 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 29545181 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X18305606 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | IGF-1 receptor | - |
dc.subject.keyword | Lipopolysaccharide | - |
dc.subject.keyword | Lung injury | - |
dc.subject.keyword | Necroptosis | - |
dc.subject.keyword | Respiratory distress syndrome | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Song, Joo Han | - |
dc.contributor.alternativeName | Leem, Ah Young | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Kyung Soo | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Song, Joo Han | - |
dc.contributor.affiliatedAuthor | Leem, Ah Young | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Kyung Soo | - |
dc.citation.volume | 498 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 877 | - |
dc.citation.endPage | 883 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.498(4) : 877-883, 2018 | - |
dc.identifier.rimsid | 59829 | - |
dc.type.rims | ART | - |
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