Cited 16 times in
Delta Neutrophil Index Is Associated with Vasculitis Activity and Risk of Relapse in ANCA-Associated Vasculitis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 유주영 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 정승민 | - |
dc.date.accessioned | 2018-08-28T17:03:16Z | - |
dc.date.available | 2018-08-28T17:03:16Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162209 | - |
dc.description.abstract | PURPOSE: Delta neutrophil index (DNI) represents the immature granulocytes count associated with neutrophil-consumption. We investigated whether DNI might be associated with Birmingham vasculitis activity score (BVAS) at diagnosis and could predict relapse during the follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). MATERIALS AND METHODS: We reviewed the medical records of 97 patients having DNI results. Twenty patients had granulomatosis with polyangiitis (GPA), 58 had microscopic polyangiitis (MPA), and 19 had eosinophilic GPA (EGPA). We collected clinical and laboratory data including BVAS, five factor score (FFS), and DNI. The correlation coefficient and cumulative relapse free survival rate were obtained. The optimal cut-off of DNI was extrapolated by calculating the area under the receiver operator characteristic curve. RESULTS: DNI was significantly related to cross-sectional BVAS. Furthermore, among continuous variables, only DNI could reflect BVAS of GPA and MPA, but not EGPA. Severe AAV was defined as BVAS >/=20 (the highest quartile). At diagnosis, patients having DNI >/=0.65% had a significantly higher risk of severe GPA and MPA than those having not (relative risk 4.255) at diagnosis. During the follow-up, DNI >/=0.65% could predict the higher relapse rate. CONCLUSION: DNI could reflect BVAS at diagnosis and furthermore, DNI >/=0.65% could not only identify severe AAV at diagnosis, but also predict relapse during the follow-up in patients with GPA and MPA. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*diagnosis/epidemiology/immunology | - |
dc.subject.MESH | Antineutrophil Cytoplasmic Antibodies | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Granulomatosis with Polyangiitis/diagnosis/epidemiology/*immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Microscopic Polyangiitis/diagnosis/epidemiology/*immunology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | *Neutrophils | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Quality of Life | - |
dc.subject.MESH | *Recurrence | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | Delta Neutrophil Index Is Associated with Vasculitis Activity and Risk of Relapse in ANCA-Associated Vasculitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Juyoung Yoo | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Seung Min Jung | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.contributor.googleauthor | Yong Beom Park | - |
dc.contributor.googleauthor | Sang Won Lee | - |
dc.identifier.doi | 10.3349/ymj.2018.59.3.397 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A05157 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A05179 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 29611402 | - |
dc.subject.keyword | Delta neutrophil index | - |
dc.subject.keyword | granulomatosis with polyangiitis | - |
dc.subject.keyword | microscopic polyangiitis | - |
dc.subject.keyword | vasculitis activity | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Song, Jung Sik | - |
dc.contributor.alternativeName | Ahn, Sung Soo | - |
dc.contributor.alternativeName | Yoo, Juyoung | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.alternativeName | Jung, SeungMin | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Song, Jung Sik | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Soo | - |
dc.contributor.affiliatedAuthor | Yoo, Juyoung | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Jung, SeungMin | - |
dc.citation.volume | 59 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 397 | - |
dc.citation.endPage | 405 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.59(3) : 397-405, 2018 | - |
dc.identifier.rimsid | 59795 | - |
dc.type.rims | ART | - |
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