49 74

Cited 2 times in

Delta Neutrophil Index Is Associated with Vasculitis Activity and Risk of Relapse in ANCA-Associated Vasculitis

DC FieldValueLanguage
dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author안성수-
dc.contributor.author유주영-
dc.contributor.author이상원-
dc.contributor.author정승민-
dc.date.accessioned2018-08-28T17:03:16Z-
dc.date.available2018-08-28T17:03:16Z-
dc.date.issued2018-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162209-
dc.description.abstractPURPOSE: Delta neutrophil index (DNI) represents the immature granulocytes count associated with neutrophil-consumption. We investigated whether DNI might be associated with Birmingham vasculitis activity score (BVAS) at diagnosis and could predict relapse during the follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). MATERIALS AND METHODS: We reviewed the medical records of 97 patients having DNI results. Twenty patients had granulomatosis with polyangiitis (GPA), 58 had microscopic polyangiitis (MPA), and 19 had eosinophilic GPA (EGPA). We collected clinical and laboratory data including BVAS, five factor score (FFS), and DNI. The correlation coefficient and cumulative relapse free survival rate were obtained. The optimal cut-off of DNI was extrapolated by calculating the area under the receiver operator characteristic curve. RESULTS: DNI was significantly related to cross-sectional BVAS. Furthermore, among continuous variables, only DNI could reflect BVAS of GPA and MPA, but not EGPA. Severe AAV was defined as BVAS >/=20 (the highest quartile). At diagnosis, patients having DNI >/=0.65% had a significantly higher risk of severe GPA and MPA than those having not (relative risk 4.255) at diagnosis. During the follow-up, DNI >/=0.65% could predict the higher relapse rate. CONCLUSION: DNI could reflect BVAS at diagnosis and furthermore, DNI >/=0.65% could not only identify severe AAV at diagnosis, but also predict relapse during the follow-up in patients with GPA and MPA.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*diagnosis/epidemiology/immunology-
dc.subject.MESHAntineutrophil Cytoplasmic Antibodies-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHGranulomatosis with Polyangiitis/diagnosis/epidemiology/*immunology-
dc.subject.MESHHumans-
dc.subject.MESHMicroscopic Polyangiitis/diagnosis/epidemiology/*immunology-
dc.subject.MESHMiddle Aged-
dc.subject.MESH*Neutrophils-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHQuality of Life-
dc.subject.MESH*Recurrence-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk-
dc.subject.MESHSeverity of Illness Index-
dc.titleDelta Neutrophil Index Is Associated with Vasculitis Activity and Risk of Relapse in ANCA-Associated Vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJuyoung Yoo-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorSeung Min Jung-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong Beom Park-
dc.contributor.googleauthorSang Won Lee-
dc.identifier.doi10.3349/ymj.2018.59.3.397-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02233-
dc.contributor.localIdA05157-
dc.contributor.localIdA02824-
dc.contributor.localIdA05179-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid29611402-
dc.subject.keywordDelta neutrophil index-
dc.subject.keywordgranulomatosis with polyangiitis-
dc.subject.keywordmicroscopic polyangiitis-
dc.subject.keywordvasculitis activity-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameSong, Jung Sik-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.alternativeNameYoo, Juyoung-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.alternativeNameJung, Seung Min -
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorSong, Jung Sik-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.contributor.affiliatedAuthorYoo, Juyoung-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.contributor.affiliatedAuthorJung, Seung Min -
dc.citation.volume59-
dc.citation.number3-
dc.citation.startPage397-
dc.citation.endPage405-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.59(3) : 397-405, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.