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The Role of Serotonin in Ventricular Repolarization in Pregnant Mice
DC Field | Value | Language |
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dc.contributor.author | 박희남 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2018-08-28T16:58:42Z | - |
dc.date.available | 2018-08-28T16:58:42Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162130 | - |
dc.description.abstract | PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role in mothers remains unclear. We evaluated the role of serotonin in ventricular repolarization in mice hearts via 5Htr3 receptor (Htr3a) and investigated the mechanism of QT-prolongation during pregnancy. MATERIALS AND METHODS: We measured current amplitudes and the expression levels of voltage-gated K(+) (Kv) channels in freshly-isolated left ventricular myocytes from wild-type non-pregnant (WT-NP), late-pregnant (WT-LP), and non-pregnant Htr3a homozygous knockout mice (Htr3a(-/-)-NP). RESULTS: During pregnancy, serotonin and tryptophan hydroxylase 1, a rate-limiting enzyme for the synthesis of serotonin, were markedly increased in hearts and serum. Serotonin increased Kv current densities concomitant with the shortening of the QT interval in WT-NP mice, but not in WT-LP and Htr3a(-/-)-NP mice. Ondansetron, an Htr3 antagonist, decreased Kv currents in WT-LP mice, but not in WT-NP mice. Kv4.3 directly interacted with Htr3a, and this binding was facilitated by serotonin. Serotonin increased the trafficking of Kv4.3 channels to the cellular membrane in WT-NP. CONCLUSION: Serotonin increases repolarizing currents by augmenting Kv currents. Elevated serotonin levels during pregnancy counterbalance pregnancy-related QT prolongation by facilitating Htr3-mediated Kv currents. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | *Action Potentials/drug effects | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Membrane/drug effects/metabolism | - |
dc.subject.MESH | Animal Disease Models | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HSC70 Heat-Shock Proteins/metabolism | - |
dc.subject.MESH | HSP90 Heat-Shock Proteins/metabolism | - |
dc.subject.MESH | Heart Ventricles/drug effects/*metabolism | - |
dc.subject.MESH | Inbred C57BL Mice | - |
dc.subject.MESH | Knockout Mice | - |
dc.subject.MESH | Cardiac/drug effects/metabolism Myocytes | - |
dc.subject.MESH | Potassium Channels/metabolism | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Sprague-Dawley Rats | - |
dc.subject.MESH | Serotonin Receptors, 5-HT3/metabolism | - |
dc.subject.MESH | Serotonin/*metabolism | - |
dc.subject.MESH | Serotonin 5-HT3 Receptor Agonists/pharmacology | - |
dc.title | The Role of Serotonin in Ventricular Repolarization in Pregnant Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Shanyu Cui | - |
dc.contributor.googleauthor | Hyewon Park | - |
dc.contributor.googleauthor | Hyelim Park | - |
dc.contributor.googleauthor | Dasom Mun | - |
dc.contributor.googleauthor | Seung Hyun Lee | - |
dc.contributor.googleauthor | Hyoeun Kim | - |
dc.contributor.googleauthor | Nuri Yun | - |
dc.contributor.googleauthor | Hail Kim | - |
dc.contributor.googleauthor | Michael Kim | - |
dc.contributor.googleauthor | Hui Nam Pak | - |
dc.contributor.googleauthor | Moon Hyoung Lee | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.3349/ymj.2018.59.2.279 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A02932 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 29436197 | - |
dc.subject.keyword | QT interval | - |
dc.subject.keyword | Serotonin receptor type 3 | - |
dc.subject.keyword | membrane trafficking | - |
dc.subject.keyword | pregnancy | - |
dc.subject.keyword | serotonin | - |
dc.subject.keyword | voltage-gated K(+) (Kv) current | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Lee, Seung Hyun | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.citation.volume | 59 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 279 | - |
dc.citation.endPage | 286 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.59(2) : 279-286, 2018 | - |
dc.identifier.rimsid | 59719 | - |
dc.type.rims | ART | - |
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