Cited 23 times in
Ethyl pyruvate is renoprotective against ischemia-reperfusion injury under hyperglycemia
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 최낙철 | - |
dc.date.accessioned | 2018-08-28T16:56:49Z | - |
dc.date.available | 2018-08-28T16:56:49Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0022-5223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162095 | - |
dc.description.abstract | BACKGROUND: Hyperglycemia (HG) is common in cardiovascular surgeries due to diabetes, inflammation, and the neuroendocrine stress response. HG aggravates renal ischemia-reperfusion (I/R) injury through an increased inflammatory response, and blunts the protective effect of various measures. Ethyl pyruvate (EP) provides anti-inflammatory effects against I/R injury via inhibition of high-mobility group box 1 protein (HMGB1) release. This study aimed to determine the renoprotective effect of EP against I/R injury under HG. METHODS: Sprague-Dawley rats were randomly assigned at random to 8 groups: normoglycemia (NG)-sham, NG-I/R-control, NG-EP-I/R (pretreatment), NG-I/R-EP (posttreatment), HG-sham, HG-I/R-control, HG-EP-I/R, and HG-I/R-EP. Renal I/R was induced by 45 minutes of ischemia (clamping of renal arteries), followed by 24 hours of reperfusion. EP (50 mg/kg) was administered intraperitoneally at 1 h before ischemia (pretreatment) or on reperfusion (posttreatment). RESULTS: I/R injury under HG significantly aggravated the degree of renal tubular apoptosis and damage compared with the NG groups, which could be attenuated by both pretreatment and posttreatment of EP. I/R-induced increases in HMGB1 and Toll-like receptors (TLRs), activation of NF-kB, and resultant alterations in interleukin-1beta, tumor necrosis factor-alpha, proapoptotic Bax, and antiapoptotic Bcl-2 were all favorably modulated by EP treatment in both the NG and HG groups compared with their corresponding control groups. CONCLUSIONS: Despite aggravation of renal I/R injury by HG through amplified inflammation, EP administration showed similar suppression of the HMGB1-TLR-NF-kB pathway in the HG and NG groups. EP retained anti-inflammatory, antiapoptotic, and renoprotective effects in the HG groups, whether administered before ischemia or on reperfusion. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mosby | - |
dc.relation.isPartOf | JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Ethyl pyruvate is renoprotective against ischemia-reperfusion injury under hyperglycemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Ji Hae Jun | - |
dc.contributor.googleauthor | Jong Wook Song | - |
dc.contributor.googleauthor | Eun-Jung Shin | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.contributor.googleauthor | Nakcheol Choi | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.identifier.doi | 10.1016/j.jtcvs.2017.10.069 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A05521 | - |
dc.relation.journalcode | J01906 | - |
dc.identifier.eissn | 1097-685X | - |
dc.identifier.pmid | 29195627 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S002252231732398X | - |
dc.subject.keyword | acute kidney injury | - |
dc.subject.keyword | ethyl pyruvate | - |
dc.subject.keyword | hyperglycemia | - |
dc.subject.keyword | ischemia-reperfusion | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Song, Jong Wook | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Choi, Nakcheol | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Song, Jong Wook | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Choi, Nakcheol | - |
dc.citation.volume | 155 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1650 | - |
dc.citation.endPage | 1658 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol.155(4) : 1650-1658, 2018 | - |
dc.identifier.rimsid | 59685 | - |
dc.type.rims | ART | - |
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