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Synergistic effects of simvastatin and bone marrow-derived mesenchymal stem cells on hepatic fibrosis
DC Field | Value | Language |
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dc.contributor.author | 김경식 | - |
dc.date.accessioned | 2018-08-28T16:54:58Z | - |
dc.date.available | 2018-08-28T16:54:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162063 | - |
dc.description.abstract | The beneficial effects of simvastatin on fibrosis in various organs have been reported. In addition, bone marrow (BM)-derived mesenchymal stem cells (MSCs) have been suggested as an effective therapy for hepatic fibrosis and cirrhosis. Recent evidence suggests that pharmacological treatment devoted to regulating stem cell function is a potential new therapeutic strategy that is drawing nearer to clinical practice. The aim of this study was to determine whether the combination treatment of simvastatin plus MSCs (Sim-MSCs) could have a synergistic effect on hepatic fibrosis in a thioacetamide (TAA)-induced cirrhotic rat model and hepatic stellate cells (HSCs). Cirrhotic livers from rats treated with Sim-MSCs exhibited histological improvement compared to those treated with simvastatin alone. Sim-MSCs combination treatment decreased hepatic collagen distribution, lowered the hydroxyproline content, and rescued liver function impairment in rats with TAA-induced cirrhosis. These protective effects were more potent with Sim-MSCs than with simvastatin alone. The upregulation of collagen-1, alpha-smooth muscle actin (alpha-SMA), transforming growth factor (TGF)-beta1, and phospho-Smad3 in cirrhotic livers was prevented by the administration of Sim-MSCs. Intriguingly, Sim-MSCs inhibited both TGF-beta/Smad3 signaling and alpha-SMA in HSCs. The Sim-MSCs combination treatment exerted strong protective effects against hepatic fibrosis by suppressing TGF-beta/Smad signaling. Simvastatin could act synergistically with MSCs as an efficient therapeutic approach for intractable cirrhosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Marrow Transplantation/*methods | - |
dc.subject.MESH | Cultured Cells | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Drug Synergism | - |
dc.subject.MESH | Liver Cirrhosis/pathology/*physiopathology/*therapy | - |
dc.subject.MESH | Liver Function Tests | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation/*methods | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Sprague-Dawley Rats | - |
dc.subject.MESH | Simvastatin/*administration & dosage | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Synergistic effects of simvastatin and bone marrow-derived mesenchymal stem cells on hepatic fibrosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Yoon Ok Jang | - |
dc.contributor.googleauthor | Sung Hoon Kim | - |
dc.contributor.googleauthor | Mee-Yon Cho | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Kyu-Sang Park | - |
dc.contributor.googleauthor | Seung-Kuy Cha | - |
dc.contributor.googleauthor | Moon Young Kim | - |
dc.contributor.googleauthor | Sei Jin Chang | - |
dc.contributor.googleauthor | Soon Koo Baik | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.02.067 | - |
dc.contributor.localId | A00299 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 29428718 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X18302900 | - |
dc.subject.keyword | Hepatic fibrosis | - |
dc.subject.keyword | Liver regeneration | - |
dc.subject.keyword | Mesenchymal stem cells | - |
dc.subject.keyword | Simvastatin | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.citation.volume | 497 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 264 | - |
dc.citation.endPage | 271 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.497(1) : 264-271, 2018 | - |
dc.identifier.rimsid | 59653 | - |
dc.type.rims | ART | - |
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