Cited 2 times in
Prostate-Specific Antigen Kinetics Following 5alpha-Reductase Inhibitor Treatment May Be a Useful Indicator for Repeat Prostate Biopsy
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.contributor.author | 박상언 | - |
dc.contributor.author | 이광석 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 허지은 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2018-08-28T16:54:38Z | - |
dc.date.available | 2018-08-28T16:54:38Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162057 | - |
dc.description.abstract | PURPOSE: To evaluate parameters for determining repeat prostate biopsy in patients with 5alpha-reductase inhibitor (5ARI) treatment after initial negative biopsy. MATERIALS AND METHODS: From January 2007 to December 2015, patients who underwent a repeat prostate biopsy after an initial negative biopsy were enrolled from multiple institutions. Serial prostate-specific antigen (PSA) levels after the initial biopsy were analyzed for PSA kinetics. Clinicopathologic variables were evaluated according to the use of 5ARIs after the initial negative biopsy. RESULTS: Of 419 patients with initial negative biopsies (median age=67.0 years, median PSA=6.31 ng/mL), 101 patients (24.1%) were diagnosed with prostate cancer at the repeat biopsy. An increase in PSA level at 18 months, compared to that at 6 months, was a predictor of a positive repeat biopsy. However, the use of 5ARIs was not identified as a predictor. Of 126 patients receiving 5ARI treatment after the initial biopsy, 30 (23.8%) were diagnosed with prostate cancer at the repeat biopsy. Increase in PSA level at more than two time points after 6 months of 5ARI treatment (odds ratio=4.84, p=0.005) was associated with cancer detection at the repeat biopsy. There were no significant 5ARI group-related differences in the detection rates of prostate and high-grade cancers (Gleason score >/=7). CONCLUSION: The effects of 5ARIs on prostate cancer detection and chemoprevention remain uncertain. However, more than two increases in PSA level after 6 months of 5ARI treatment may indicate the presence of prostate cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 5-alpha Reductase Inhibitors/*therapeutic use | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | *Biopsy | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kinetics | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prostate-Specific Antigen/*blood | - |
dc.subject.MESH | Prostatic Neoplasms/blood/*drug therapy/*pathology | - |
dc.title | Prostate-Specific Antigen Kinetics Following 5alpha-Reductase Inhibitor Treatment May Be a Useful Indicator for Repeat Prostate Biopsy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Ji Eun Heo | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Sang Un Park | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Kwang Suk Lee | - |
dc.identifier.doi | 10.3349/ymj.2018.59.2.219 | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A01486 | - |
dc.contributor.localId | A02668 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A05531 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 29436189 | - |
dc.subject.keyword | 5alpha-reductase inhibitors | - |
dc.subject.keyword | Prostate biopsy | - |
dc.subject.keyword | prostate-specific antigen | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.alternativeName | Park, Sang Un | - |
dc.contributor.alternativeName | Lee, Kwang Suk | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Heo, Ji Eun | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | Park, Sang Un | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Suk | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Heo, Ji Eun | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | 이광석 | - |
dc.contributor.affiliatedAuthor | 허지은 | - |
dc.contributor.affiliatedAuthor | 구교철 | - |
dc.contributor.affiliatedAuthor | 홍성준 | - |
dc.contributor.affiliatedAuthor | 박상언 | - |
dc.contributor.affiliatedAuthor | 정병하 | - |
dc.citation.volume | 59 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 219 | - |
dc.citation.endPage | 225 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.59(2) : 219-225, 2018 | - |
dc.identifier.rimsid | 59647 | - |
dc.type.rims | ART | - |
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