Cited 11 times in
Neuronal Nitric Oxide Synthase Is a Novel Biomarker for the Interstitial Cells of Cajal in Stress-Induced Diarrhea-Dominant Irritable Bowel Syndrome
DC Field | Value | Language |
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dc.contributor.author | 남기택 | - |
dc.date.accessioned | 2018-08-28T16:48:42Z | - |
dc.date.available | 2018-08-28T16:48:42Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161964 | - |
dc.description.abstract | BACKGROUND: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder involving changes in normal bowel movements. The pathophysiology of IBS is not clearly understood owing to the lack of identifiable pathological abnormalities and reliable biomarkers. AIM: The aim of this study was to discover the novel and reliable biomarker for IBS. METHOD: In this study, neonatal maternal separation (NMS) stress model was used for the IBS mouse model. Further assessment was conducted with whole gastrointestinal transit test, quantitative RT-PCR, histological examination, and western blot. RESULTS: Male pups developed symptoms similar to those of human IBS with diarrhea (IBS-D), such as low-grade inflammation, stool irregularity, and increased bowel motility. NMS stress influenced to the interstitial cells of Cajal (ICC) and induced altered bowel motility, resulting in IBS-D-like symptoms. In addition, we found neuronal nitric oxide synthase (nNOS) to be a novel biomarker for ICC under NMS stress. nNOS expression was only observed in the ICC of the submucosal plexus of IBS-D mice, and the inhibition of nNOS changed the phenotype from IBS-D to IBS with constipation. CONCLUSION: Our study demonstrates that early-life stress can influence to ICC and modulate bowel activity and that nNOS might be used as a biomarker for ICC stimulation in IBS. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Science + Business Media | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Newborn Animals | - |
dc.subject.MESH | Biomarkers/metabolism | - |
dc.subject.MESH | Diarrhea/enzymology/etiology/pathology | - |
dc.subject.MESH | Animal Disease Models | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrointestinal Motility | - |
dc.subject.MESH | Interstitial Cells of Cajal/*pathology | - |
dc.subject.MESH | Irritable Bowel Syndrome/*enzymology/*etiology/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Maternal Deprivation | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Inbred C57BL Mice | - |
dc.subject.MESH | Nitric Oxide Synthase/*metabolism | - |
dc.subject.MESH | Psychological/*complications Stress | - |
dc.title | Neuronal Nitric Oxide Synthase Is a Novel Biomarker for the Interstitial Cells of Cajal in Stress-Induced Diarrhea-Dominant Irritable Bowel Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Da Eun Jang | - |
dc.contributor.googleauthor | Ji Hyun Bae | - |
dc.contributor.googleauthor | Yoo Jin Chang | - |
dc.contributor.googleauthor | Yoon Hoo Lee | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | Il Yong Kim | - |
dc.contributor.googleauthor | Je Kyung Seong | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.contributor.googleauthor | Su Cheong Yeom | - |
dc.identifier.doi | 10.1007/s10620-018-4933-7 | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J00737 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.identifier.pmid | 29372479 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10620-018-4933-7 | - |
dc.subject.keyword | Interstitial cells of Cajal | - |
dc.subject.keyword | Neonatal maternal separation | - |
dc.subject.keyword | Neuronal nitric oxide synthase | - |
dc.subject.keyword | irritable bowel syndrome | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | Nam, Ki Taek | - |
dc.citation.volume | 63 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 619 | - |
dc.citation.endPage | 627 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, Vol.63(3) : 619-627, 2018 | - |
dc.identifier.rimsid | 59555 | - |
dc.type.rims | ART | - |
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