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Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study

 Jung Ran Choi  ;  Jang Young Kim  ;  Il Hwan Park  ;  Ji Hye Huh  ;  Ki Woo Kim  ;  Seung Kuy Cha  ;  Kyu Sang Park  ;  Joon Hyung Sohn  ;  Jong Taek Park  ;  Sang Baek Koh 
 Yonsei Medical Journal, Vol.59(2) : 287-293, 2018 
Journal Title
 Yonsei Medical Journal 
Issue Date
Biomarkers/blood ; Female ; Fibroblast Growth Factors/*blood ; Humans ; Male ; Metabolic Syndrome/*blood ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Prospective Studies
Metabolic syndrome ; biomarker ; fibroblast growth factor 21 ; population-based prospective study
PURPOSE: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population-based prospective study. MATERIALS AND METHODS: We conducted a prospective study of 221 randomly sampled adults without MetS from a general population-based cohort study who were examined from 2005-2008 (baseline) and from 2008-2011 (follow-up). Baseline serum FGF21 levels were analyzed using enzyme-linked immunosorbent assay. RESULTS: During the average 2.8-year follow-up period, 82 participants (36.6%) developed new-onset MetS. Serum FGF21 levels were significantly higher in patients with new-onset MetS than in those without MetS (209.56+/-226.80 vs. 110.09+/-81.10, p<0.01). In multivariate adjusted models, the odds for MetS development were greater in patients with serum FGF21 levels in the highest quartile, compared to those in the lowest quartile (3.84, 95% confidence interval: 1.59-9.28). CONCLUSION: Serum FGF21 level was an independent predictor for new-onset MetS in a population-based prospective study.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Woo(김기우) ORCID logo https://orcid.org/0000-0002-7790-1515
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