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Fluorescence-guided Surgery with Splenic Preservation Prevents Tumor Recurrence in an Orthotopic Nude-mouse Model of Human Pancreatic Cancer

Authors
 Ho Kyoung Hwang  ;  Chang Moo Kang  ;  Sung Hwan Lee  ;  Takashi Murakami  ;  Tasuku Kiyuna  ;  Se Hoon Kim  ;  Robert M Hoffman  ;  Michael Bouvet 
Citation
 Anticancer Research, Vol.38(2) : 665-670, 2018 
Journal Title
 Anticancer Research 
ISSN
 0250-7005 
Issue Date
2018
MeSH
Animals ; Tumor Cell Line ; Fluorescence ; Humans ; Nude Mice ; Local Neoplasm Recurrence ; Organ Sparing Treatments/*methods ; Pancreatic Neoplasms/*pathology/*surgery ; Spleen/pathology/*surgery ; Splenectomy/*methods ; Xenograft Model Antitumor Assays
Keywords
Fluorescence-guided surgery ; green fluorescent protein ; nude mice ; orthotopic ; pancreatic cancer ; recurrence ; splenectomy
Abstract
AIM: The purpose of this study was to investigate whether splenectomy influences tumor recurrence after fluorescence-guided surgery (FGS) in an orthotopic nude-mouse model of pancreatic cancer. MATERIALS AND METHODS: Green fluorescence protein (GFP)-labeled human pancreatic cancer cells (MiaPaCa2-GFP) were subcutaneously injected into the flanks of nude mice. Subcutaneous tumors were harvested and surgical orthotopic implantation (SOI) was performed in the tail of the pancreas with small tumor fragments. FGS was performed 21 days after SOI. Mice were then randomly divided into FGS-only control group (n=7) and FGS plus splenectomy group (n=8). Tumor recurrence was analyzed by laparotomy 21 days after FGS. RESULTS: In the control group, no recurrence was found. In contrast, multiple peritoneal seeded nodules were observed in two mice of the splenectomy group (0% vs. 25%, p=0.467). CONCLUSION: Postoperative tumor recurrence only occurred in the splenectomy-treated group suggesting that FGS can spare the patient the morbidity of splenectomy.
Full Text
http://ar.iiarjournals.org/content/38/2/665.abstract
DOI
10.21873/anticanres.12270
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
강창무(Kang, Chang Moo) ORCID logo https://orcid.org/0000-0002-5382-4658
김세훈(Kim, Se Hoon) ORCID logo https://orcid.org/0000-0001-7516-7372
황호경(Hwang, Ho Kyoung) ORCID logo https://orcid.org/0000-0003-4064-7776
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161920
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