Cited 27 times in
Effects of genetic variants on platelet reactivity and one-year clinical outcomes after percutaneous coronary intervention: A prospective multicentre registry study.
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2018-08-28T16:46:04Z | - |
dc.date.available | 2018-08-28T16:46:04Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161914 | - |
dc.description.abstract | Clopidogrel is the mainstay for antiplatelet treatment after percutaneous coronary intervention (PCI). The relationship of platelet reactivity and genetic polymorphism with clinical outcomes with newer-generation drug-eluting stents is unclear. We analysed 4,587 patients for the most powerful single-nucleotide polymorphisms (CYP2C19, CYP2C9, ABCB1, PON1, and P2Y12) related to on-treatment platelet reactivity (OPR). The optimal cut-off value of high OPR for major adverse thrombotic events was 266. CYP2C19 was significantly associated with high OPR and the number of CYP2C19*R (*2 or *3) alleles was proportional to the increased risk of high OPR. Death, myocardial infarction (MI), stroke, stent thrombosis, and bleeding events were assessed during a 1-year follow-up period. Primary endpoints were death and non-fatal MI. The cumulative 1-year incidence of death and stent thrombosis was significantly higher in patients with CYP2C19*2/*2, CYP2C19*2/*3, and CYP2C19*3/*3 (Group 3) than in patients with CYP2C19*1/*1 (Group 1). Multivariate Cox proportional hazard model showed that cardiac death risk was significantly higher in Group 3 than in Group 1 (hazard ratio 2.69, 95% confidence interval 1.154-6.263, p = 0.022). No association was reported between bleeding and OPR. Thus, CYP2C19 may exert a significant impact on the prognosis of PCI patients even in the era of newer-generation drug-eluting stents. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of genetic variants on platelet reactivity and one-year clinical outcomes after percutaneous coronary intervention: A prospective multicentre registry study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hyung Joon Joo | - |
dc.contributor.googleauthor | Sung Gyun Ahn | - |
dc.contributor.googleauthor | Jae Hyoung Park | - |
dc.contributor.googleauthor | Ji Young Park | - |
dc.contributor.googleauthor | Soon Jun Hong | - |
dc.contributor.googleauthor | Seok-Yeon Kim | - |
dc.contributor.googleauthor | WoongGil Choi | - |
dc.contributor.googleauthor | HyeonCheol Gwon | - |
dc.contributor.googleauthor | Young-Hyo Lim | - |
dc.contributor.googleauthor | Weon Kim | - |
dc.contributor.googleauthor | Woong Chol Kang | - |
dc.contributor.googleauthor | Yun-Hyeong Cho | - |
dc.contributor.googleauthor | Yong Hoon Kim | - |
dc.contributor.googleauthor | JungHan Yoon | - |
dc.contributor.googleauthor | WonYong Shin | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Scot Garg | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Do-Sun Lim | - |
dc.identifier.doi | 10.1038/s41598-017-18134-y | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04391 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 29352151 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1229 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.8(1) : 1229, 2018 | - |
dc.identifier.rimsid | 59505 | - |
dc.type.rims | ART | - |
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