Cited 140 times in
Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남기택 | - |
dc.contributor.author | 유성숙 | - |
dc.date.accessioned | 2018-08-28T16:44:46Z | - |
dc.date.available | 2018-08-28T16:44:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161898 | - |
dc.description.abstract | Supramolecular chemistry provides a "bottom-up" method to fabricate nanostructures for biomedical applications. Herein, we report a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission and singlet oxygen generation associated with the formation of free PcS, mild photothermal heating, and a concomitant chemotherapeutic effect associated with the formation of free MA. In vivo evaluations indicate that PcS-MA nanostructures have a high level of accumulation in tumor tissues, are capable of being used for cancer imaging, and have significantly improved anticancer effect compared to that of PcS. This study demonstrates an attractive strategy for overcoming the limitations of photodynamic cancer therapy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | ACS NANO | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Xingshu Li | - |
dc.contributor.googleauthor | Sungsook Yu | - |
dc.contributor.googleauthor | Dayoung Lee | - |
dc.contributor.googleauthor | Gyoungmi Kim | - |
dc.contributor.googleauthor | Buhyun Lee | - |
dc.contributor.googleauthor | Yejin Cho | - |
dc.contributor.googleauthor | Bi-Yuan Zheng | - |
dc.contributor.googleauthor | Mei-Rong Ke | - |
dc.contributor.googleauthor | Jian-Dong Huang | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | Xiaoyuan Chen | - |
dc.contributor.googleauthor | Juyoung Yoon | - |
dc.identifier.doi | 10.1021/acsnano.7b07809 | - |
dc.contributor.localId | A01243 | - |
dc.contributor.localId | A02473 | - |
dc.relation.journalcode | J00005 | - |
dc.identifier.eissn | 1936-086X | - |
dc.identifier.pmid | 29232105 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsnano.7b07809 | - |
dc.subject.keyword | activatable | - |
dc.subject.keyword | nanotheranostics | - |
dc.subject.keyword | nucleic-acid-responsive disassembly | - |
dc.subject.keyword | photodynamic therapy | - |
dc.subject.keyword | supramolecular assembly | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.alternativeName | Yu, Sungsook | - |
dc.contributor.affiliatedAuthor | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | Yu, Sungsook | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 681 | - |
dc.citation.endPage | 688 | - |
dc.identifier.bibliographicCitation | ACS NANO, Vol.12(1) : 681-688, 2018 | - |
dc.identifier.rimsid | 59489 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.