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Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy

Authors
 Xingshu Li  ;  Sungsook Yu  ;  Dayoung Lee  ;  Gyoungmi Kim  ;  Buhyun Lee  ;  Yejin Cho  ;  Bi-Yuan Zheng  ;  Mei-Rong Ke  ;  Jian-Dong Huang  ;  Ki Taek Nam  ;  Xiaoyuan Chen  ;  Juyoung Yoon 
Citation
 ACS Nano, Vol.12(1) : 681-688, 2018 
Journal Title
 ACS Nano 
ISSN
 1936-0851 
Issue Date
2018
Keywords
activatable ; nanotheranostics ; nucleic-acid-responsive disassembly ; photodynamic therapy ; supramolecular assembly
Abstract
Supramolecular chemistry provides a "bottom-up" method to fabricate nanostructures for biomedical applications. Herein, we report a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission and singlet oxygen generation associated with the formation of free PcS, mild photothermal heating, and a concomitant chemotherapeutic effect associated with the formation of free MA. In vivo evaluations indicate that PcS-MA nanostructures have a high level of accumulation in tumor tissues, are capable of being used for cancer imaging, and have significantly improved anticancer effect compared to that of PcS. This study demonstrates an attractive strategy for overcoming the limitations of photodynamic cancer therapy.
Full Text
https://pubs.acs.org/doi/10.1021/acsnano.7b07809
DOI
10.1021/acsnano.7b07809
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
Yu, Sungsook(유성숙)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161898
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